Purchase this article with an account.
Fernando R. Zanetti, Sr., Enzo Fulco, Sr., Fernando r. Chaves, Sr., Alexandre P. Pinto, Sr., Fabio E. Hirata, Mauricio A. Nascimento, Sr., Carlos E. Arieta, Sr., Rodrigo P. Lira, Sr.; Effect Of Preoperative Use Of Topical Anti-inflammatory Prednisolone Acetate, Ketorolac Thrometamine, Nepafenac And Placebo, On The Maintenance Of Intraoperative Mydriasis In Cataract Surgery: A Randomized Controlled Trial. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4711.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare the effects of preoperative use of topical anti-inflammatoryprednisolone acetate, ketorolac thrometamine, nepafenac andplacebo, on the maintenance of intraoperative mydriasis in cataractsurgery.
This was a masked, single-center, randomized clinical studycomprised 140 patients undergoing phacoemulsification cataractsurgery. Patients were randomized to receive either placebocarboxymethylcellulose sodium 0.5%, prednisolone acetate 1%,ketorolac thrometamine 0.4% or nepafenac 0.1%. Theses dropswere administered 48 hours before surgery in a mask fashion.Digital photos of the pupil were taken preoperatively, at thebeginning of the surgery, and post-operatively, immediatelyat the end of the surgery. The magnification was done previouslyby placing a millimeter scale under the microscope. The primaryendpoint was to measure the efficacy of each medication to inhibitmiosis (to achieve pupils > 6mm at the end of the surgery).The secondary outcome was to achieve pupils > 6mm at thebeginning of the surgery.
The comparison of the prednisolone, nepafenac and thrometaminegroups with the placebo group was statistically significant(p<0.005) in the maintenance of intraoperative mydriasis.All the patients to achieve preoperative mydriasis > 6mmat the beginning of the surgery.
Prophylactic use of ketorolac, prednisolone and nepafenac waseffective in maintaining intraoperative mydriasis and can beused in surgical practice with similar effectiveness.
This PDF is available to Subscribers Only