April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Effect Of Preoperative Use Of Topical Anti-inflammatory Prednisolone Acetate, Ketorolac Thrometamine, Nepafenac And Placebo, On The Maintenance Of Intraoperative Mydriasis In Cataract Surgery: A Randomized Controlled Trial
Author Affiliations & Notes
  • Fernando R. Zanetti, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Enzo Fulco, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Fernando r. Chaves, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Alexandre P. Pinto, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Fabio E. Hirata
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Mauricio A. Nascimento, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Carlos E. Arieta, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Rodrigo P. Lira, Sr.
    Otolaryngology/Ophthalmology, Unicamp, Campinas, Brazil
  • Footnotes
    Commercial Relationships  Fernando R. Zanetti, Sr., None; Enzo Fulco, Sr., None; Fernando R. Chaves, Sr., None; Alexandre P. Pinto, Sr., None; Fabio E. Hirata, None; Mauricio A. Nascimento, Sr., None; Carlos E. Arieta, Sr., None; Rodrigo P. Lira, Sr., None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4711. doi:
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      Fernando R. Zanetti, Sr., Enzo Fulco, Sr., Fernando r. Chaves, Sr., Alexandre P. Pinto, Sr., Fabio E. Hirata, Mauricio A. Nascimento, Sr., Carlos E. Arieta, Sr., Rodrigo P. Lira, Sr.; Effect Of Preoperative Use Of Topical Anti-inflammatory Prednisolone Acetate, Ketorolac Thrometamine, Nepafenac And Placebo, On The Maintenance Of Intraoperative Mydriasis In Cataract Surgery: A Randomized Controlled Trial. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4711.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose:
 

To compare the effects of preoperative use of topical anti-inflammatoryprednisolone acetate, ketorolac thrometamine, nepafenac andplacebo, on the maintenance of intraoperative mydriasis in cataractsurgery.

 
Methods:
 

This was a masked, single-center, randomized clinical studycomprised 140 patients undergoing phacoemulsification cataractsurgery. Patients were randomized to receive either placebocarboxymethylcellulose sodium 0.5%, prednisolone acetate 1%,ketorolac thrometamine 0.4% or nepafenac 0.1%. Theses dropswere administered 48 hours before surgery in a mask fashion.Digital photos of the pupil were taken preoperatively, at thebeginning of the surgery, and post-operatively, immediatelyat the end of the surgery. The magnification was done previouslyby placing a millimeter scale under the microscope. The primaryendpoint was to measure the efficacy of each medication to inhibitmiosis (to achieve pupils > 6mm at the end of the surgery).The secondary outcome was to achieve pupils > 6mm at thebeginning of the surgery.

 
Results:
 

The comparison of the prednisolone, nepafenac and thrometaminegroups with the placebo group was statistically significant(p<0.005) in the maintenance of intraoperative mydriasis.All the patients to achieve preoperative mydriasis > 6mmat the beginning of the surgery.

 
Conclusions:
 

Prophylactic use of ketorolac, prednisolone and nepafenac waseffective in maintaining intraoperative mydriasis and can beused in surgical practice with similar effectiveness.  

 

 
Clinical Trial:
 

http://www.clinicaltrials.gov NCT00865540

 
Keywords: cataract • corticosteroids 
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