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Yukihisa Takada, Yuka Okada, Ai Kitano, Nobuyuki Ishikawa, Norihito Fujita, Shizuya Saika; Effects Of The Eye Drops Of Prostaglandin Analogs On Corneal Epithelial Wound Healing. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4794.
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© ARVO (1962-2015); The Authors (2016-present)
Prostaglandin (PG) analogs are widely used for the treatment of glaucoma. The purpose of this study was to examine the effects of eye drops of PG analogs on corneal epithelial wound healing.
1) Effects of the eye drops of PG (Xalatan® (Latanoprost; Pfizer), Travatanz® (Travoprost; Alcon), Tapros® (Tafluprost; Santen) and Lumigan® (Bimatoprost; Senju); x100 or x1000) on SV40-immortalized human cornealepithelial cell line (HCEC) migration were examined subsequent to wounding confluent monolayer cultures. 2) Alamar blue staining evaluated the effects these eye drops on HCEC proliferation. 3) Corneal blocks (2x4mm) obtained from a rabbit cornea were incubated for 24h with or without these eye drops.
1) With Tapros®, the closure of wound area was significantly accelerated compared to control (p<0.05). 2) There is no effects for HCEC proliferation with these eye drops. 3) In culture of rabbit corenal blocks, addition of Travatanz® or Tapros® to the medium decreased epithelial spreading (p<0.05).
These PG eye drops facilitated wound healing in cultured HCEC sheet and in organ cultured model. These findings suggest that these eye drops play a role in corneal epithelial cell migration and proliferation.
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