April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Non-invasive Detailed Imaging of the Vascular Network Combined with Oral Flourescein Angiography
Author Affiliations & Notes
  • Amiram Grinvald
    Neurobiology, Weizmann Inst of Science, Rehovot, Israel
  • Zvia Burgansky-Eliash
    Ophthalmology, The Edith Wolfson Medical Center, Holon, Israel
  • Darin A. Nelson
    Optical Imaging, Ltd, Rehovot, Israel
  • Hila Barash
    Optical Imaging, Ltd, Rehovot, Israel
  • Adiel Barak
    Ophthalmology, Sourasky Medical Center, Tel aviv, Israel
  • Anat Lowenstein
    Ophthalmology, Sourasky Medical Center, Tel aviv, Israel
  • Footnotes
    Commercial Relationships  Amiram Grinvald, Optical Imaging, Ltd (I, P); Zvia Burgansky-Eliash, Optical Imaging, Ltd (E); Darin A. Nelson, Optical Imaging, Ltd (E); Hila Barash, Optical Imaging, Ltd (E); Adiel Barak, None; Anat Lowenstein, None
  • Footnotes
    Support  Optical Imaging, Ltd
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4798. doi:
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      Amiram Grinvald, Zvia Burgansky-Eliash, Darin A. Nelson, Hila Barash, Adiel Barak, Anat Lowenstein; Non-invasive Detailed Imaging of the Vascular Network Combined with Oral Flourescein Angiography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4798.

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      © ARVO (1962-2015); The Authors (2016-present)

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To compensate for deficiencies of two clinical methodologieswe used the Retinal Function Imager (RFI, Optical Imaging, Ltd)to study non-invasively the fine capillaries r network and combinedit with minimally invasive oral Flourescein Angiography (FA)to assess leakage.


The RFI enables visualization of fine vascular details withoutcontrast agent injection by using erythrocyte motion contrast.Eleven patients with diabetic retinopathy, 8 patients with veinocclusion and 2 patients with central serous choroiretinopathywere enrolled to this study. All patients had multiple RFI retinalimage series. The pixel value distribution parameters were analyzedto locate blood cells motion. If leakage was suspected, oralFA study was done using the RFI device. The RFI images werecompared to standard FA.


The nCPM images revealed fine vasculature and avascular areasin good correspondence to areas shown on the intravenous FA(figure 1). Additional oral FA imaging reveals plasma leakagein different pathologies (figure 1, 2).


The RFI's nCPM revealed detailed vasculature and ischemic areaswithout contrast agent injection. The additional informationabout plasma leakage obtained by the RFI oral FA mode completesthe information. Further follow up of changes in capillariescan be done with the nCPM. This approach can serves as an importanttool for frequent monitoring of capillaries perfusion status.  


Keywords: imaging/image analysis: clinical • retina • blood supply 

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