March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Intraocular Pressure After Penetrating Keratoplasty And Dsaek : A Comparative Study
Author Affiliations & Notes
  • Rony Rachmiel
    Ophthalmology, Tel Aviv University, Rishon Le-Zion, Israel
  • Elad Moisseive
    Ophthalmology, Tel Aviv University, Rishon Le-Zion, Israel
  • David Varrssano
    Ophthalmology, Tel Aviv University, Rishon Le-Zion, Israel
  • Footnotes
    Commercial Relationships  Rony Rachmiel, None; Elad Moisseive, None; David Varrssano, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4483. doi:
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      Rony Rachmiel, Elad Moisseive, David Varrssano; Intraocular Pressure After Penetrating Keratoplasty And Dsaek : A Comparative Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4483.

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      © ARVO (1962-2015); The Authors (2016-present)

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To compare the intraocular pressure (IOP) during the first postoperative year after penetrating keratoplasty (PK) and descemet’s stripping automated endothelial keratoplasty (DSAEK).


A retrospective review of the records of 53 pseudophakic eyes ( 53 patients) that underwent PK or DSAEK due to endothelial dysfunction between January 2006 and December 2010 . Surgeries consisted of 19 (35.8%) PK procedures and 34 (64.2%) DSAEK procedures. Demographic, pre-operative and post-operative data including: intraocular pressure (IOP), number of medications, rejection occurrence and complications were recorded.


Patients who had undergone DSAEK had statistically significant lower IOP over 12 months following surgery than those who had undergone PK (p=0.028), despite similar use of IOP-lowering medications during this time. Measurements of postoperative IOP over 21 mmHg and over 30 mmHg were significantly more common in patients who had undergone PK than DSAEK. Complication rates were similar between the two groups. IOP was not correlated with patient age, gender, background illnesses or previous glaucoma.


Intraocular pressure is significantly lower after DSAEK compared to penetrating keratoplasty. Several mechanisms explaining this difference have been proposed. New corneal transplantation modalities such as DSAEK , with a better IOP control, may lower the risk of later visual loss due to postoperative glaucomatous damage.

Clinical Trial:

Tel Aviv medical Center registry, 1234

Keywords: intraocular pressure 

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