March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
CDKN2B Polymorphism Is Associated With POAG In The Afro-caribbean Population Of Barbados
Author Affiliations & Notes
  • Xiaodong Jiao
    OGVFB, National Eye Institute, Rockville, Maryland
  • Dan Cao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Anselm Hennis
    University of the West Indies, Ministry of Health, Bridgetown, Barbados
  • Barbara Nemesure
    School of Medicine, Stony Brook University, Stony Brook, New York
  • M. Cristina Leske
    School of Medicine, Stony Brook University, Stony Brook, New York
  • James Hejtmancik
    OGVFB, National Eye Institute, Rockville, Maryland
  • Footnotes
    Commercial Relationships  Xiaodong Jiao, None; Dan Cao, None; Anselm Hennis, None; Barbara Nemesure, None; M. Cristina Leske, None; James Hejtmancik, None
  • Footnotes
    Support  EY000272
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4494. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Xiaodong Jiao, Dan Cao, Anselm Hennis, Barbara Nemesure, M. Cristina Leske, James Hejtmancik; CDKN2B Polymorphism Is Associated With POAG In The Afro-caribbean Population Of Barbados. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4494. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To investigate the association of common variants in or near CDC7/TGFBR3, ZP4, SRBD1, ELOVL5, CAV1/CAV2, TLR4, CDKN2B, CDKN2B-AS1, ATOH7, PLXDC2, TMTC2, SIX1 and CARD10, previously reported to be associated with glaucoma in the literature, with primary open angle glaucoma (POAG) in the Afro-Caribbean population of Barbados.

Methods: : A total of 440 unrelated subjects were recruited for this study, including 274 with POAG and 166 unaffected individuals. Eighteen SNPs were genotyped by using the multiplex SNaPshot method. Allelic, genotypic and model-based (dominant, recessive and additive) associations of the SNPs with POAG were analyzed by Chi-squared test and logistic regression.

Results: : SNP rs1063192 is significantly associated with POAG (allelic P=0.0008, genotypic P=0.0029). The minor allele C of rs1063192 was protective against POAG (OR = 0.39; 95%CI = 0.22-0.69). Suggestive association was seen with rs7916697 (allelic P = 0.0096, genotypic P = 0.01) with the minor allele also being protective (OR = 0.67; 95% CI = 0.50-0.91), although this did not withstand correction for multiple testing. However, a significant interactive effect on POAG risk was identified between rs1063192 and rs7916697 (P-interaction = 2.80 x 10-5). Individuals with rs1063192 protective genotype CC or CT and also rs7916697 genotypes GG or GA have a significantly decreased risk of POAG (OR=0.17, 95%CI: 0.07-0.41).

Conclusions: : Our study confirmed a significant association between SNP rs1063192 (CDKN2B, previously shown to influence vertical cup-to-disc ratio) at 9p21 and POAG in the Afro-Caribbean population of Barbados. The minor allele of rs1063192 acts interactively with that of rs7916697 (ATOH7) to reduce POAG risk. Our results also suggest that rs1063192 is a common protective variant for POAG in populations of both European descent and African descent.

Keywords: genetics • gene mapping • candidate gene analysis 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×