March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Association Between Estrogen Receptor Beta Gene Polymorphisms And Intraocular Pressure Elevation In Women
Author Affiliations & Notes
  • Fumihiko Mabuchi
    Ophthalmology,
    University of Yamanashi, Chuo-shi, Japan
  • Yoichi Sakurada
    Ophthalmology,
    University of Yamanashi, Chuo-shi, Japan
  • Kenji Kashiwagi
    Ophthalmology,
    University of Yamanashi, Chuo-shi, Japan
  • Zentaro Yamagata
    Health Sciences,
    University of Yamanashi, Chuo-shi, Japan
  • Hiroyuki Iijima
    Ophthalmology,
    University of Yamanashi, Chuo-shi, Japan
  • Shigeo Tsukahara
    Ophthalmology,
    University of Yamanashi, Chuo-shi, Japan
  • Footnotes
    Commercial Relationships  Fumihiko Mabuchi, None; Yoichi Sakurada, None; Kenji Kashiwagi, None; Zentaro Yamagata, None; Hiroyuki Iijima, None; Shigeo Tsukahara, None
  • Footnotes
    Support  Takeda Science Foundation
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4501. doi:
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      Fumihiko Mabuchi, Yoichi Sakurada, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima, Shigeo Tsukahara; Association Between Estrogen Receptor Beta Gene Polymorphisms And Intraocular Pressure Elevation In Women. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : We previously reported that estrogen receptor beta (ESR2) gene polymorphism (rs1256031) was associated with an intraocular pressure (IOP) elevation in female patients with POAG. The aim of this study was to confirm the association between ESR2 gene polymorphisms and IOP in women.

Methods: : Eight tag single nucleotide polymorphisms covering the ESR2 region (rs1256031, rs4986938, rs1256049, rs1273916, rs1256120, rs928554, rs1256059, and rs944461) were genotyped in 326 Japanese female patients, including the patients with normal tension glaucoma (NTG, n = 122), high tension glaucoma (HTG, n = 83), and 121 control subjects. Maximum IOP was compared between the genotypes using an analysis of variance (ANOVA).

Results: : There were statistically significant differences in the maximum IOP between the genotypes of the rs1256031, rs928554, and rs1256059 (P = 0.0034, P = 0.040, and P = 0.032 respectively, ANOVA). The maximum IOPs in patients with the rs1256031 CC (20.3 ± 7.2 mmHg, mean ± standard deviation) or TC (19.8 ± 7.5 mmHg) genotypes were significantly higher (P = 0.0023 and P = 0.0039, respectively) than that in patients with the TT (17.5 ± 4.1 mmHg) genotype. Similarly, the maximum IOP (20.9 ± 8.2 mmHg) in patients with the rs928554 GG genotype was significantly higher (P = 0.015) than that (18.3 ± 5.6 mmHg) in patients with the AA genotype, and the maximum IOP (20.9 ± 8.2 mmHg) in patients with the rs1256059 TT genotype was significantly higher (P = 0.012) than that (18.2 ± 5.7 mmHg) in patients with the CC genotype.

Conclusions: : These results strongly suggest that the ESR2 gene polymorphisms are associated with IOP elevation in women.

Keywords: intraocular pressure • gene screening • genetics 
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