March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Choroidal Thickness In Retinitis Pigmentosa
Author Affiliations & Notes
  • Empar Sanz-Marco
    Hospital Universitario y Politecnico La Nueva Fe, Valencia, Spain
  • Roberto Gallego-Pinazo
    Hospital Universitario y Politecnico La Nueva Fe, Valencia, Spain
  • David Salom
    Hospital Universitario y Politecnico La Nueva Fe, Valencia, Spain
  • J Fernando Arevalo
    Vitreoretinal Division, Fundación Arévalo-Coutinho, Caracas, Venezuela
  • Manuel Diaz-Llopis
    Hospital Universitario y Politecnico La Nueva Fe, Valencia, Spain
  • Footnotes
    Commercial Relationships  Empar Sanz-Marco, None; Roberto Gallego-Pinazo, None; David Salom, None; J Fernando Arevalo, None; Manuel Diaz-Llopis, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4582. doi:
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      Empar Sanz-Marco, Roberto Gallego-Pinazo, David Salom, J Fernando Arevalo, Manuel Diaz-Llopis; Choroidal Thickness In Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4582.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Most of oxygen and glucose consumption in retina (65-75%) is supplied by the choroid. The choroid is involved in important diseases affecting the optic nerve, RPE, and retina, as an integral constituent in the functioning of the eye. By using the spectral-domain optical coherence tomography (SD-OCT) closer to the eye, the deeper structures are placed closer to zero-delay. The acquired images have improved ability to visualize the choroid, and the thickness of the choroid can be measured. Different studies have used enhanced depth imaging (EDI) OCT (Spectralis®, Heidelberg Engineering, Heidelberg, Germany) and Cirrus HD-OCT® (Carl Zeiss Meditec, Dublin, CA, USA) for this purpose. The aim of this study was to characterize CT in patients with RP using SD-OCT and to analyze its prognostic functional value.

Methods: : Cross-sectional retrospective analysis. 24 eyes of 12 patients with RP and 26 eyes of 13 healthy age-matched controls were analyzed. CT was measured with high-definition horizontal 1-line raster scans through the foveal center, with spectral-domain optical coherence tomography (Cirrus HD-OCT®). Measures were collected from the subfoveolar space, from 2000μm, 1500μm, 1000μm, 500μm temporal and nasal from foveola in RP patients and in control subjects. A complete ophthalmic evaluation was performed in RP patients including: best corrected visual acuity, fundus photography, autofluorescence and visual field. T-Student, and Pearson correlation test were used for statistical analysis.

Results: : No epidemiological differences were observed between both groups. CT was significantly decreased in RP patients compared with control group in all measuring points (p<0.001). The foveal CT was positively correlated with the mean diameter of preserved autofluorescence (temporal P=0.632 p=0.001; subfoveolar P=0.491 p=0.017; nasal: P=0.582 p=0.004), visual acuity (temporal: P=0.511 p=0.013; subfoveolar P=0.426 p=0.042), the sum of the threshold sensibility in four quadrants (temporal: P=0.554 p=0.006; subfoveolar: P=0.452 p=0.031; nasal: P=0.416 p=0.049). However it was not correlated with the mean of hyperautofluorescent ring nor preserved degrees in VF. Age was not correlated with choroidal thickness at any point in any group, it presumably due to the homogeneus age in each cluster (P>0.05).

Conclusions: : This study demonstrates CT is decreased in patients with RP compared with age-matched healthy controls. In addition, choroidal thinning is correlated with poor visual function in RP patients. CT might be a new objective measurement in the evaluation of RP patients. Further studies are needed to confirm our preliminary observations.

Keywords: choroid • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retinal degenerations: hereditary 
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