March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Comparison Of Optical Coherence Tomography Macular Findings In 5 Year-old Patients With A History Of Pre-threshold Or Threshold Retinopathy Of Prematurity Treated With Intravitreal Bevacizumab As Monotherapy
Author Affiliations & Notes
  • Jose A Hernandez-Vargas
    Asociacion Para Evitar la Ceguera en Mexico, IAP, Mexico, Mexico
  • Fernando Schoonewolff
    Retina, Asoc Para Evitar la Ceguera en Mexico, Mexico, Mexico
  • Veronica E. Giordano
    Retina, Asoc Para Evitar la Ceguera en Mexico, Distrito Federal, Mexico
  • Andrea Portilla-Demichelis
    Asociacion Para Evitar la Ceguera en Mexico, IAP, Mexico, Mexico
  • Ana I. Ortiz
    Retina- Col San Lucas Coyoacan, APEC, Mexico City, Mexico
  • Robison V. Chan
    Ophthalmology, Weill Cornell Medical College, New York, New York
  • Hugo Quiroz-Mercado
    Ophthalmology, Denver Health Medical Center, Denver, Colorado
  • Maria A. Martinez-Castellanos
    Retina and Vitreous, Asociacion Para Evitar la Ceguera, Mexico, Mexico
  • Footnotes
    Commercial Relationships  Jose A Hernandez-Vargas, None; Fernando Schoonewolff, None; Veronica E. Giordano, None; Andrea Portilla-Demichelis, None; Ana I. Ortiz, None; Robison V. Chan, None; Hugo Quiroz-Mercado, None; Maria A. Martinez-Castellanos, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4683. doi:
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      Jose A Hernandez-Vargas, Fernando Schoonewolff, Veronica E. Giordano, Andrea Portilla-Demichelis, Ana I. Ortiz, Robison V. Chan, Hugo Quiroz-Mercado, Maria A. Martinez-Castellanos; Comparison Of Optical Coherence Tomography Macular Findings In 5 Year-old Patients With A History Of Pre-threshold Or Threshold Retinopathy Of Prematurity Treated With Intravitreal Bevacizumab As Monotherapy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4683.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the optical coherence tomography (OCT) macular findings in 5 year-old patients with a history of pre-threshold or threshold retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IB) as monotherapy.

Methods: : In a case-control study, iVUE OCT (OptoVue) imaging of the macula was performed on 5 year-old patients with history of ROP treated with intravitreal bevacizumab. The same OCT imaging was performed in healthy patients who were born full-term and were 5 years of age at time of imaging. The findings were correlated with ophthalmoscopy and visual acuity.

Results: : Nine eyes of 5 patients were treated with IB for threshold or pre-threshold ROP between september 2005 and June 2006. Mean gestational age at birth was 29.2 weeks. The 9 eyes had a median best-corrected visual acuity of 0.01 logMAR. The control group had 0.00 logMAR. The OCT showed a normal macular depression in both groups, mean thickness 202 µm (range 184-218 µm) in the ROP group and mean 210 µm (range 173-234 µm) in the control group, p=0.0001. No vitreoretinal disorders were observed.

Conclusions: : OCT imaging showed no anatomical difference or macular thikness between both groups. Larger studies should be performed to confirm these findings.

Clinical Trial: : http://www.clinicaltrials.gov NCT00346814

Keywords: retinopathy of prematurity 
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