Comparison Of Optical Coherence Tomography Macular Findings In 5 Year-old Patients With A History Of Pre-threshold Or Threshold Retinopathy Of Prematurity Treated With Intravitreal Bevacizumab As Monotherapy

Abstract

Purpose: : To compare the optical coherence tomography (OCT) macular findings in 5 year-old patients with a history of pre-threshold or threshold retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IB) as monotherapy.

Methods: : In a case-control study, iVUE OCT (OptoVue) imaging of the macula was performed on 5 year-old patients with history of ROP treated with intravitreal bevacizumab. The same OCT imaging was performed in healthy patients who were born full-term and were 5 years of age at time of imaging. The findings were correlated with ophthalmoscopy and visual acuity.

Results: : Nine eyes of 5 patients were treated with IB for threshold or pre-threshold ROP between september 2005 and June 2006. Mean gestational age at birth was 29.2 weeks. The 9 eyes had a median best-corrected visual acuity of 0.01 logMAR. The control group had 0.00 logMAR. The OCT showed a normal macular depression in both groups, mean thickness 202 µm (range 184-218 µm) in the ROP group and mean 210 µm (range 173-234 µm) in the control group, p=0.0001. No vitreoretinal disorders were observed.

Conclusions: : OCT imaging showed no anatomical difference or macular thikness between both groups. Larger studies should be performed to confirm these findings.

Clinical Trial: : http://www.clinicaltrials.gov NCT00346814

Keywords: retinopathy of prematurity