March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Proliferative Retinopathy of Prematurity is Associated with Low Serum Levels of Adiponectin
Author Affiliations & Notes
  • Chatarina Lofqvist
    Ophthalmology/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • Ingrid Hansen Pupp
    Pediatrics/Clinical Sciences, Lund University, Lund, Sweden
  • Jing Chen
    Ophthalmology, Harvard Med Sch Children's Hosp, Boston, Massachusetts
  • Colman J. Hatton
    Ophthalmology, Children's Hospital Boston, Boston, Massachusetts
  • Aimee Juan
    Ophthalmology, Children's Hospital Boston, Boston, Massachusetts
  • David Ley
    Pediatrics/Clinical Sciences, Lund University, Lund, Sweden
  • Gunnel Hellgren
    Pediatrics/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • Lois E. Smith
    Ophthalmology, Harvard Univ/Childrens Hospital, Boston, Massachusetts
  • Ann Hellstrom
    Ophthalmology/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • Footnotes
    Commercial Relationships  Chatarina Lofqvist, None; Ingrid Hansen Pupp, None; Jing Chen, None; Colman J. Hatton, None; Aimee Juan, None; David Ley, None; Gunnel Hellgren, None; Lois E. Smith, None; Ann Hellstrom, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4687. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Chatarina Lofqvist, Ingrid Hansen Pupp, Jing Chen, Colman J. Hatton, Aimee Juan, David Ley, Gunnel Hellgren, Lois E. Smith, Ann Hellstrom; Proliferative Retinopathy of Prematurity is Associated with Low Serum Levels of Adiponectin. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4687.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract 
 
Purpose:
 

Adiponectin (APN) is almost exclusively produced by adipose tissue. Adiponectin production is downregulated by weight gain, angiotensin II, oxidative stress, and testosterone as well as proinflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6. In the oxygen-induced mouse model of ROP APN suppresses TNF-α-induced inflammatory changes and blocks retinal neovascularization. Furthermore, an association between APN serum levels and postnatal growth of preterm infants has been reported. Since we have found previously a link between poor postnatal growth and later development of proliferative ROP, these results suggest a potential link between APN and development of ROP. The aim of this study was to investigate if there is a link between postnatal longitudinal development of serum adiponectin levels after birth and ROP.

 
Methods:
 

A prospective cohort study was performed in twenty-four extremely preterm infants (median (range) gestational age (GA) 25.2 (23.0-27.00) weeks with weekly blood sampling of adiponectin from birth to PMA 36 weeks. ROP was determined according to the International ROP classification.

 
Results:
 

Sixteen children had no signs of any ROP and eight infants had proliferative ROP. Adiponectin levels at birth were low in both groups and showed a similar continuous increase occurring up to postmenstrual age (PMA) 30 weeks irrespective of GA at birth (Fig). For both groups between PMA 24 to 31 weeks adiponectin levels increased 10-fold, then rapidly decreased. There was a significant correlation between mean adiponectin levels at PMA 33-36 weeks and mean weight SDS at PMA 33-36 weeks (r2=0.40 p=0.001). Furthermore infants who developed proliferative ROP, had significantly lower levels of adiponectin between PMA 33-36 weeks (corresponding to the time for the induction of proliferative ROP) compared to the group with no ROP, p=0.019.

 
Conclusions:
 

Our results show that the serum level of adiponectin is lower during the proliferative phase, in infants who develop severe ROP. Further studies of the mechanism of action and expression are necessary to determine if the correlation between circulating levels of adiponectin and retinal neovascularization is causal or merely secondary to postnatal weight gain.  

 
Keywords: retinopathy of prematurity 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×