April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Evidence of a Compensation Mechanism between Corneal and Internal Ocular Optical Aberrations in Patients with Keratoconus
Author Affiliations & Notes
  • Kata Mihaltz
    Ophthalmology, Semmelweis University, Budapest, Hungary
  • Illés Kovács
    Ophthalmology, Semmelweis University, Budapest, Hungary
  • Zoltán Z. Nagy
    Ophthalmology, Semmelweis University, Budapest, Hungary
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5166. doi:
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      Kata Mihaltz, Illés Kovács, Zoltán Z. Nagy; Evidence of a Compensation Mechanism between Corneal and Internal Ocular Optical Aberrations in Patients with Keratoconus. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5166.

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Abstract

Purpose: : To explore the nature of a compensation mechanism between corneal and internal ocular aberrations using combined wavefront analysis and corneal topography in eyes with keratoconus.

Methods: : The study comprised 43 eyes of patients with keratoconus and 41 control patients. Total ocular, corneal and internal wavefront measurements were provided by the NIDEK OPD-Scan II. Correlations between the individual corneal and internal aberrations were evaluated using correlation matrices in the two groups.

Results: : Significantly higher corneal wavefront error (5.5±3.1µm) and internal (5.3±3.5) wavefront error aberrations were observed in eyes with keratoconus (p<0.001) compared to normals (corneal: 1.03±0.6, internal: 2.6±1.7). However, an increase in total ocular aberrations proportional to corneal and internal aberrations could not be observed in the keratoconus (4.5±2.39) and in the control (2.7±1.8) groups. Correlation matrix of corneal and internal ocular aberrations showed close negative correlation between corneal and internal vertical tilt (r=-0.96, p<0.001), oblique astigmatism (r=-0.83, p<0.001) and vertical coma (r=-0.95, p<0.001) in the keratoconus group. A similar, but less pronounced tendency could be observed in the control group: vertical tilt (r=-0.55, p<0.001), oblique astigmatism (r=-0.58, p<0.001) and vertical coma (r=-0.53, p<0.001).

Conclusions: : A reducing effect of increased anterior corneal aberrations in keratoconic eyes is present, which is probably due to a compensation mechanism by internal optics.

Keywords: keratoconus • cornea: clinical science • optical properties 
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