April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Corneal Biomechanical Properties in Normal and Myopic Eyes as Assessed by the Ocular Response Analyzer
Author Affiliations & Notes
  • Jeremias G. Galletti
    Ophthalmology, Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina
    Special Studies Section, Pförtner Laboratory, Buenos Aires, Argentina
  • Marianella Delrivo
    Special Studies Section, Pförtner Laboratory, Buenos Aires, Argentina
  • Tomás Pförtner
    Special Studies Section, Pförtner Laboratory, Buenos Aires, Argentina
  • Fernando Fuentes Bonthoux
    Ophthalmology, Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina
    Special Studies Section, Pförtner Laboratory, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  Jeremias G. Galletti, None; Marianella Delrivo, None; Tomás Pförtner, None; Fernando Fuentes Bonthoux, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5179. doi:
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      Jeremias G. Galletti, Marianella Delrivo, Tomás Pförtner, Fernando Fuentes Bonthoux; Corneal Biomechanical Properties in Normal and Myopic Eyes as Assessed by the Ocular Response Analyzer. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5179.

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Abstract
 
Purpose:
 

To evaluate corneal biomechanics in normal and myopic eyes, taking into account the effect of corneal thickness on Ocular Response Analyzer (ORA) measurements.

 
Methods:
 

52 eyes from 52 healthy subjects in group 1 and 97 eyes from 97 myopic subjects [spherical equivalent (SE) < -5D] were evaluated with ORA, corneal topography, aberrometry and anterior segment optical coherence tomography. Linear regression analysis applied to an independent calibration sample of 103 eyes from 103 identically evaluated, healthy subjects yielded equations relating corneal hysteresis (CH) and corneal resistance factor (CRF) to central corneal thickness (CCT). Difference from the predicted CH and CRF for a given CCT was computed as DifCH and DifCRF for each eye.

 
Results:
 

Significant positive correlations were found between both CH and CRF and CCT in the calibration sample. In group 1 vs group 2, CCT (mean±SEM, 521.0±5.357 vs 515.8±3.545) and average corneal power (ACP) (43.80±0.2436 vs 44.04±0.1809) did not differ significantly, but anterior chamber depth (ACD) was significantly higher in the myopic group (3.068±0.07259 vs 3.228±0.03538, p=0.03). Mean CH (10.02±0.1856 vs 9.466±0.1645, p=0.04) and CRF (9.937±0.1863 vs 9.122±0.1878, p=0.01) were reduced in group 2. Mean DifCRF (0.2402±0.1591 vs -0.4680±0.1690, p=0.01), but not mean DifCH (0.1077±0.1765 vs -0.3546±0.1515, p=0.06), was significantly lower in group 2. SE was positively correlated to DifCRF (r=0.1780, p=0.03) but not to DifCH (r=0.1412, p=0.09).

 
Conclusions:
 

Both CH and CRF were reduced in myopic eyes, but when the influence of CCT was accounted for, only DifCRF remained significantly lower. Both groups had similar mean corneal thickness and curvature, thus intrinsic differences in corneal composition must account for the aforementioned discrepancies in myopic eyes. CRF seems to be a more reliable indicator of biomechanical weakness than CH, and correlation to CCT could increase the usability of both ORA parameters.  

 
Keywords: cornea: clinical science • myopia • cornea: stroma and keratocytes 
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