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Alice Grise-Dulac, Jr., Alain Saad, Jean-Luc Febbraro, Damien Gatinel; Biomechanical Properties Of The Cornea In Normal Tension Glaucoma And Comparison With Open Angle Glaucoma, Ocular Hypertension And Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5181.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the biomechanical properties of the corneas, in normal tension glaucoma (NTG) patients and to compare them with those of patients with primary open angle glaucoma (POAG), ocular hypertension (OHT) and normal patients (N).
Corneal hysteresis (CH), Corneal resistance factor (CRF), Goldmann intraocular pressure (IOPg) and IOP corneal-compensed (IOPcc) were provided by ORA device for 28 eyes of 14 patients with NTG, 75 eyes of 38 patients with chronic POAG, 53 eyes of 27 patients with OHT and 34 eyes of 17 N subjects. Intraocular pressure measured with Goldmann applanation tonometry (IOP-GA) and ultrasonic central corneal thickness (CCT) were also measured for each eye. ANOVA test and Pearson correlation were used for statistical analysis.
CRF was significantly lower in the NTG group (9.5 +/- 1.89 mmHg) compared to the POAG group (11.15 +/- 2.35 mmHg: p<0.01) and to the N group (11.13 +/- 1.81 mmHg: p<0.01). CCT was not significantly different between the 4 groups. IOPcc was significantly lower in NTG group compared to the POAG group and OHT group group (p<0.001). Analysis of signal curves characteristics differentiates the OHT group from the NTG group with a sensitivity of 94.3%, the POAG group from the NTG group with a sensibility of 90% and the POAG group from the OHT group with a sensibility of 90.7%.
NTG was associated with CRF significantly lower than chronic POAG and normal subjects. CRF could be usefull in early diagnosis of NTG.
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