Purchase this article with an account.
Savvakis hadjiraftis, Michael Haustein, Eberhard Spoerl, Lutz E. Pillunat; The Influence Of Corneal Biomechanical Parameters On Ocular Blood Flow In Different Glaucoma Stages, Ocular Hypertension And In Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5183.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the correlation of corneal properties with ocular blood flow (OBF) and ocular pulse amplitude (OPA) in different glaucoma stages, ocular hypertension and healthy eyes.
In this prospective study 653 eyes of 296 patients and 59 healthy volunteers were examined. Glaucoma stages were graded by cup to disc ratio (CDR) and visual field defects into: 1. pre-perimetric, 2. moderate, and 3. advanced. The Ocular Response Analyzer (ORA) was used to obtain CH (corneal hysteresis) and CRF (corneal resistance factor) in the different groups. Ocular blood flow (OBF) and pulse amplitude (PA) were measured by OBF. CH and CRF were then correlated to OBF and PA parameters.
The repeatability of IOPg, IOPcc, CRF and CH was 4.08 mmHg (95% confidence interval: 3.06-5.09), 4.72 mmHg (3.54-5.89) , 2.14 mmHg (1.61-2.68) and 2.35 mmHg (1.77-2.94) in healthy subjects and 4.18 mmHg (3.75-4.61), 5.56 mmHg (4.99-6.14), 2.17 mmHg (1.95-2.40) and 2.78 mmHg (2.50-3.07) in the glaucoma group. However, CH and CRF were not statistically significantly associated to OBF and PA in both groups. OBF was significantly associated to IODcc, IODg and uncorrected IOD (P=0.006, P=0.012 and P=0.001). PA was significantly associated to axial length (P=0.004).
In the present study CRF and CH were not significantly associated to changes of OBF or ocular pulse amplitude (OPA).
This PDF is available to Subscribers Only