April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Influence of a Loading Phase on Long-term Visual Acuity with Respect to Genetic and Clinical Factors in Patients with Neovascular Age-related Macular Degeneration
Author Affiliations & Notes
  • Moreno Menghini
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
  • Florian K. Sutter
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
  • Barbara Kloeckener-Gruissem
    Institute of Medical Molecular Genetics, University of Zurich, Schwerzenbach, Switzerland
  • Johannes C. Fleischhauer
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
  • Malaika M. Kurz
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
  • Sandrine A. Zweifel
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
  • Stephan Michels
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
    Ophthalmology, Triemli Hospital Zurich, Zurich, Switzerland
  • Wolfgang Berger
    Institute of Medical Molecular Genetics, University of Zurich, Schwerzenbach, Switzerland
  • Daniel Barthelmes
    Division of Ophthalmology, University Hospital of Zurich, Zurich, Switzerland
    Save Sight Institute, University of Sydney, Sydney, Australia
  • Footnotes
    Commercial Relationships  Moreno Menghini, None; Florian K. Sutter, None; Barbara Kloeckener-Gruissem, None; Johannes C. Fleischhauer, None; Malaika M. Kurz, None; Sandrine A. Zweifel, None; Stephan Michels, None; Wolfgang Berger, None; Daniel Barthelmes, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5243. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Moreno Menghini, Florian K. Sutter, Barbara Kloeckener-Gruissem, Johannes C. Fleischhauer, Malaika M. Kurz, Sandrine A. Zweifel, Stephan Michels, Wolfgang Berger, Daniel Barthelmes; Influence of a Loading Phase on Long-term Visual Acuity with Respect to Genetic and Clinical Factors in Patients with Neovascular Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5243. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

The ideal treatment regimen in patients with neovascular age-related macular degeneration is still being investigated. Widely applied is a loading phase with initially three consecutive intravitreal injections of ranibizumab. The influence of genetic risk factors on AMD has been repeatedly published. Recent studies have shown a higher number of patients requiring re-injections. Furthermore, CFH genotypes have been implicated with a varying outcome. The purpose of this study was to compare the outcome of patients with loading phase to patients without with respect to genetic polymorphisms and clinical components.

 
Methods:
 

Retrospective analysis of the clinical data of neovascular AMD patients treated with intravitreal ranibizumab during a follow up period of at least 12 months. Assessment of the injection frequency and course of VA was performed. Calculation of the proportion of patients having initially received three consecutive intravitreal injections (loading phase) of ranibizumab with allocation to two groups: Group 1 eyes with loading phase; Group 2 eyes without loading phase. Genotypes at SNP rs1061170 in CFH were identified and their frequency was compared between the two groups.

 
Results:
 

A total of 238 eyes were included in the final analyses with 62 eyes allocated to Group 1 and 176 eyes to Group 2. Demographic characteristics and baseline visual acuity were comparable between the two groups. The injection frequency over a period of 12 months showed a median of 5 (Interquartile-Range IQR [3;7]) in Group 1 and a median of 4 [2.5;6] in Group 2 (p=0.074). The median change in VA from baseline was 4 letters [-5;12] in Group 1 and 2 [-5;10] in Group 2 (p=0.463). 16 eyes (26%) in Group 1 carried the genotype CC CFH rs106117 as opposed to 51 (29%) in Group 2, (p=0.743). Eyes carrying the risk factor CC CFH in Group 1 showed a similar median outcome compared to Group 2: 0[-6;8] and -5[-8;6] (p=0.463).

 
Conclusions:
 

Loading phase did not appear to influence positive treatment outcome. Furthermore, it seems that patients carrying the known AMD susceptibility locus CFH do not show a better improvement with a loading phase.

 
Keywords: age-related macular degeneration • choroid: neovascularization • genetics 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×