April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Association of FPR1 with Exudative Age-related Macular Degeneration
Author Affiliations & Notes
  • Xiao Ying Liang
    Dept. of Ophthalmology & Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Li jia Chen
    Dept. of Ophthalmology & Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Pancy O. Tam
    Dept. of Ophthalmology & Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland
  • Chi Pui Pang
    Dept. of Ophthalmology & Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Footnotes
    Commercial Relationships  Xiao Ying Liang, None; Li jia Chen, None; Pancy O. Tam, None; Chi Chao Chan, None; Chi Pui Pang, None
  • Footnotes
    Support  a block grant from the University Grants Committee and the Endowment Fund for Lim Por-Yen Eye Genetics Research Centre, Hong Kong
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5253. doi:
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    • Get Citation

      Xiao Ying Liang, Li jia Chen, Pancy O. Tam, Chi Chao Chan, Chi Pui Pang; Association of FPR1 with Exudative Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5253.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The pathogenesis of age-related macular degeneration (AMD) is initiated by inflammation, in which formyl peptide receptor 1 (FPR1) is an important regulator. This study aims to explore the association of FPR1 gene with exudative AMD in a Hong Kong Chinese cohort.

Methods: : A total of 155 exudative AMD patients and 220 age-matched control subjects from was recruited. All coding exons and exon-intron boundaries of the FPR1 gene were screened by polymerase chain reaction and direct sequencing.

Results: : A total of 25 polymorphisms were identified. Eleven were novel. Three polymorphisms, c.289C>A (Leu97Met; p = 0.043), c.576T>G (Asn192Lys; p = 0.037) and c.1053+196C>T (p = 0.003), were associated with exudative AMD. However, the amino acid changes were not conserved across species in the multiple sequence alignment. In addition, 5 rare variants were found although their frequency in AMD patients was similar to that in control subjects (7/148 vs 17/203; p = 0.211).

Conclusions: : This study revealed that the FPR1 gene is associated exudative AMD, further supporting the involvement of inflammation in AMD pathogenesis.

Keywords: age-related macular degeneration • inflammation • gene screening 
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