April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Association Study Between Mitochondrial Dna Polymorphisms And Risk Of Age-related Macular Degeneration
Author Affiliations & Notes
  • Julien Tilleul, Jr.
    ophthalmology, Hopital intercommunal de Creteil - Paris 12, Creteil, France
  • Florence Richard
    Institut Pasteur de Lille, Lille, France
  • Nathalie Puche
    ophthalmology, Hopital intercommunal de Creteil - Paris 12, Creteil, France
  • Jennyfer Zerbib
    ophthalmology, Hopital intercommunal de Creteil - Paris 12, Creteil, France
  • Nicolas Leveziel
    ophthalmology, Hopital intercommunal de Creteil - Paris 12, Creteil, France
  • Arnold Munnich
    genetics, Unité Inserm U781 - hopital Necker-Enfants-Malades, Paris, France
  • Josseline Kaplan
    genetics, Unité Inserm U781 - hopital Necker-Enfants-Malades, Paris, France
  • Jean-Michel Rozet
    genetics, Unité Inserm U781 - hopital Necker-Enfants-Malades, Paris, France
  • Eric H. Souied
    ophthalmology, Hopital intercommunal de Creteil - Paris 12, Creteil, France
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5266. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Julien Tilleul, Jr., Florence Richard, Nathalie Puche, Jennyfer Zerbib, Nicolas Leveziel, Arnold Munnich, Josseline Kaplan, Jean-Michel Rozet, Eric H. Souied; Association Study Between Mitochondrial Dna Polymorphisms And Risk Of Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5266.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : The objective of the study was to analyze the relationship between polymorphisms of the mitochondrial genome and age macular degeneration (AMD) through a case control study in a large French series.

Methods: : Based on a candidate gene approach, we analyzed several polymorphisms of the mitochondrial genome: 4917G, 11812G (which both define the mitochondrial T2 haplogroup) and 14470 (T/C/A) in a French series of 1224 patients with neovascular AMD and 559 controls. CFH and ARMS2 genotypes had previously been performed. Patients’ genotypes were determined by PCR/sequencing.

Results: : No association was found between the T2 haplogroup and AMD in this European cohort (adjusted OR = 0.9 [0.5 - 1.5]). An association was found with 14470 when analyzing crude OR: patients having 14470 C or 14470A had a decreased risk of having neovascular AMD; however this association disappeared when OR were adjusted on age, sex, tobacco, CFH and ARMS2 status because patients having these genotypes were younger than patients having the 14470T genotype, particularly in controls.

Conclusions: : Association between AMD and T2 haplogroup, previously described in North American populations, was not found in our French series. 14470 polymorphism, clearly linked with age in controls, could be associated with longevity.

Keywords: age-related macular degeneration • genetics • mitochondria 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×