April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Changes of Anterior Chamber Angle Configuration after Laser Peripheral Iridotomy in Primary Angle-closure Suspects: Early Gonioscopic Outcome of the Zhongshan Angle-closure Prevention Study
Yuzhen Jiang; Mingguang He; David S. Friedman; Shengsong Huang; Tin Aung; Paul J. Foster
Author Affiliations & Notes
  • Yuzhen Jiang
    Preventive Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Mingguang He
    Preventive Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
    National Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom
  • David S. Friedman
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
  • Shengsong Huang
    Preventive Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Tin Aung
    Glaucoma, Singapore National Eye Center, Singapore, Singapore
  • Paul J. Foster
    Epidemiology, UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships  Yuzhen Jiang, None; Mingguang He, None; David S. Friedman, None; Shengsong Huang, None; Tin Aung, None; Paul J. Foster, None
  • Footnotes
    Support  Fight for Sight (UK), Sun Yat-sen University 5010 Project Fund (China)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5319. doi:
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      Yuzhen Jiang, Mingguang He, David S. Friedman, Shengsong Huang, Tin Aung, Paul J. Foster; Changes of Anterior Chamber Angle Configuration after Laser Peripheral Iridotomy in Primary Angle-closure Suspects: Early Gonioscopic Outcome of the Zhongshan Angle-closure Prevention Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5319.

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Abstract

Purpose: : To determine the early changes in gonioscopic findings after laser peripheral iridotomy (LPI) in a large sample of community-based primary angle closure suspects (PACS).

Methods: : Subjects identified as primary angle-closure suspects aged 50-70 years were treated with LPI in a randomly selected eye whereas the fellow eyes served as controls. Findings from gonioscopy and limbal anterior chamber depth exam before treatment and 2 weeks and 6 months after treatment were compared.

Results: : A total of 717 subjects participated in this study. The proportion of steep iris profile under static gonioscopy changed from 79.6% before LPI to 9.0% two weeks after LPI and 11.4% at six months (P<0.001). The median number of quadrants in which the iridotrabecular angle width was below 20 degrees (Shaffer grade ≤2) changed from 4 to 1 at two weeks after LPI and to 2 at six months. After LPI, 24.6% and 31.9% of treated eyes still had at least two quadrants in which the posterior trabecular meshwork could not been seen under static gonioscopy at two weeks and six months after LPI, respectively. The proportions of eyes in which PTM was not visible in at least 3 quadrants decreased from 89.6% before LPI to 12.5% two weeks after LPI and 16.3% at six months (P<0.001). Median limbal anterior chamber depth score changed from 25% before LPI to 40% at six month (P<0.001). All of the angle findings remained constant at 2 weeks and six months in the control eyes (p > 0.05).

Conclusions: : LPI significantly widens the anterior chamber angle on goinioscopy in primary angle closure suspects. As compared to two weeks after LPI, anterior chamber angle was significantly narrower at six month after LPI.

Clinical Trial: : http://www.controlled-trials.com, ISRCTN45213099

Keywords: clinical (human) or epidemiologic studies: outcomes/complications • anterior segment • laser 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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