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Sayana Tea, Mathieu Barrali, Jr., Evelyne Racadot, Bernard Delbosc; Assessment Of Thrombophilic And Fibrinolytic Abnomalities In Retinal Vein Occlusion Of Patients Under 60 Years Of Age. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5392.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study was to investigate the prevalence of thrombophilic and fibrinolytic factors of patients with central retinal vein occlusion (CRVO) under 60 years of age.
Prospective, observational study of 21 patients with CRVO compared with a matched control group of 23 volunteers. All participant were screened for : risk of cardiovascular disease, lipid levels, homocysteine, MTHFR genotype, antiphospholipid antibodies (anticardiolipin antibodies, circulating anticoagulant, antiB2GP1 antibodies, antiprothrombin antibodies, antiannexin V antibodies), antithrombin III ( AT III), protein C and S, resistance to activated protein C, factor V Leiden mutation, prothrombin mutation, protein Z and protein Z antibodies, factor VIII, IX, X, XI and XII, plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), thrombin generation test.
There was a statistically significantly higher rate for having at least one thrombophilic predisposing factor in CRVO patients ( P=0,018). The most common factors were: hypercholesterolemia (42,8% vs 18,2%), hyperhomocysteinemia (22,8% vs 0%), AT III deficiency (14,3% vs 4,3%), high factor VIII (26,3% vs 11,7%). The frequency of t-PA D/D genotype was 30% vs 13,6%, and the factor VIII the VAL/VAL genotype was 61,9% in both groups. 66% of CRVO cases had a risk of cardiovascular disease. The frequency of thrombolysis abnormalities was the same with or without risk factors.
Exhaustif thrombophilic laboratory tests should be realised for patients less than 60 years of age with CRVO. No significant differencies were found in the prevalence of fibrinolytic factors. Screening for cardiovascular risk factors is recommended even in young patients.
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