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Abdullah S. Alqahtani, Valerie Touitou, Helene Merle-Beral, Bahram Bodaghi, Christine Fardeau, Phuc LeHoang, Nathalie Cassoux; Effectiveness Of Following The Vitreoretinal Lymphoma Response To Treatment By Measuring Anterior Chamber Il-10. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4941.
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To evaluate the effectiveness of measuring anterior chamber interleukin (IL)-10 concentrations during treatment of primary vitreoretinal lymphoma with intravitreal injection of methotrexate.
Retrospective observational case series: Patients were diagnosed having vitreoretinal lymphoma by diagnostic vitrectomy. Treatment protocol included induction course of injections of 800 microg/0.1 mlMTX intravitrealy twice weekly for 4 weeks. IL-10 concentrations in the anterior chamber were measured at baseline and at the last injections using a standard enzyme-linked immunoassay. Informationswere collected from the patient records retrospectively.
In the study 14 files were reviewed, mean age was 66 years(with a range of 44 to 81 ) ,10 out of 14 have moderate to severe vitreal infiltration(71%) ,11 patients (79%) had RPE irregularities ,average delay ofdiagnosis was 6.9 months. Eight eyes of 7 patients were treated with IVT methotrexate. Clinical remission, evaluated on clearance of vitreous malignant cells, was reached after the course of treatment with IVT methotrexate in 7 eyes out of 8 .The mean of IL10 at the diagnosis in those 8 eyes was 1045 pg/ml (range of 145 pg/ml -2500 pg/ml) while it decrease to 41 pg/ml at the end of treatment (range of 0 pg/ml -202 pg/ml) . None of the patients had an intraocular recurrence with a mean follow-up of 6 months. Two out of the 8 eyes (25%) experienced corneal epitheliopathy, which usually appeared at the beginning and subside few weeks after the end of treatment.
A decrease in the IL-10 seems to be related to a decrease in vitreous infiltrate. Measuring the IL-10 in the anterior chamber is observer independent and may be useful to evaluate therapeutic efficacy in vitreoretinal lymphoma. This method could be used for future treatment trial to free observer variability.
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