April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Treatment Outcome of Acanthamoeba Keratitis in Fukuoka University
Author Affiliations & Notes
  • Ryota Koh
    Department of Ophthalmology, Fukuoka University, Fukuoka, Japan
  • Jane Y. Huang
    Ophthalmology, Fukuoka Univ School of Medicine, Fukuoka, Japan
  • Masahiko Kozawa
    Department of Ophthalmology, Fukuoka University, Fukuoka, Japan
  • Eiichi Uchio
    Ophthalmology, Fukuoka Univ Sch of Medicine, Jonan, Japan
  • Footnotes
    Commercial Relationships  Ryota Koh, None; Jane Y. Huang, None; Masahiko Kozawa, None; Eiichi Uchio, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 5834. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ryota Koh, Jane Y. Huang, Masahiko Kozawa, Eiichi Uchio; Treatment Outcome of Acanthamoeba Keratitis in Fukuoka University. Invest. Ophthalmol. Vis. Sci. 2011;52(14):5834.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Outbreaks of acanthamoeba keratitis (AK) have been increasing recently in Japan. The purpose of this study is to examine the treatment outcome of AK in Fukuoka University in recent 4 years.

Methods: : We report on 15 eyes 15 cases of AK diagnosed and treated between 2007 and 2010 at Fukuoka University. All cases were diagnosed either based on positive microbial finding from corneal scrapings or contact lens (CL) cases, or by typical clinical manifestaions of AK. We evaluated the length of treatment, type of CL used, therapeutic success, and visual outcomes.

Results: : Fifteen eyes of 15 patients were diagnosed as AK. Seven out of 15 eyes (46.6%) were acanthamoeba positive from microbial culture of corneal scrapings or CL cases. Remaining 8 eyes (53.3%) were diagnosed based on typical findings of radialkeratitis. All cases were CL users with usage of soft CL (SCL) in 14 eyes and hard CL (HCL) in 1 eye. Among the SCL users, the frequent replacement type was used in 11 eyes (79%). Eight eyes (53%) were diagnosed for herpetic keratitis at previous clinic before referring to Fukuoka University. All cases underwent a protocol of topical 0.03% chlorhexidine gluconate and antimycotic drugs, regular corneal scraping, and 12 cases underwent additional treatment of systemic pentamidine isetionate. The average period of use of pentamidine isetionate were 8.5 days. Two cases required therapeutic keratoplasty (DALK). Average follow-up period was 6.1 months with improvement in visual acuity in 14 eyes. The average visual acuity improved from 0.1 (LogMAR 0.9) to 0.6 (LogMAR 0.2) at last follow-up date.

Conclusions: : Early diagnosis and treatment of AK is critical for good visual prognosis. Systemic usage of pentamidine isetionate seem to be effective in AK.

Keywords: Acanthamoeba 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.