April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Altered Ocular Perfusion In Glaucoma Patients: Differences Of Blood Flow Velocities In Retrobulbar Vessels
Lars Wagenfeld; Maren Klemm; Peter Galambos; Ralf Praga; Anne Wiermann; Gisbert Richard; Oliver Zeitz
Author Affiliations & Notes
  • Lars Wagenfeld
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
  • Maren Klemm
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
  • Peter Galambos
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
  • Ralf Praga
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
  • Anne Wiermann
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
    Department of Neurology, University of Munich, Munich, Germany
  • Gisbert Richard
    Department of Ophthalmology, University Medical Center Hamburg, Hamburg, Germany
  • Oliver Zeitz
    Global Clinical Development, Bayer HealthCare AG, Berlin, Germany
  • Footnotes
    Commercial Relationships  Lars Wagenfeld, None; Maren Klemm, None; Peter Galambos, None; Ralf Praga, None; Anne Wiermann, None; Gisbert Richard, None; Oliver Zeitz, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6026. doi:
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      Lars Wagenfeld, Maren Klemm, Peter Galambos, Ralf Praga, Anne Wiermann, Gisbert Richard, Oliver Zeitz; Altered Ocular Perfusion In Glaucoma Patients: Differences Of Blood Flow Velocities In Retrobulbar Vessels. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6026.

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Abstract

Purpose: : Primary open angle glaucoma is associated with impaired ocular perfusion. This diminished blood flow can be detected when its regulation is challenged, e.g. by flicker stimulation of the retina or after posture change. As this requires a combination of a method for measurement of ocular perfusion with a procedure to challenge ocular blood flow regulation, examination of this is very extensive and associated with discomfort for the patient. As this limits the application of such methods in clinical routine and in studies, the present work aims to investigate ocular perfusion without any stimulation of regulation mechanisms to get insight whether a simple measurement of ocular blood flow can be used in clinical routine.

Methods: : N=298 glaucoma patients and N=86 control subjects were examined in a supine position by color Doppler imaging. A Siemens Elegra device with a 7.5L40 ultrasound transducer was used. The peak systolic velocity (PSV), the end diatolic velocity (EDV), and the resistivity index (RI) were measured in the central retinal artery (CRA) and the ophthalmic artery (OA).

Results: : Blood flow parameters were measured as follows:CRA/PSV: 10.1+/-1.2 in controls vs. 8.7+/-1.2 cms-1 in glaucoma patients (P<0.001)CRA/EDV: 2.0+/-1.9 in controls vs. 1.6+/-1.4 cms-1 in glaucoma patients (P<0.001)CRA/RI: 0.8 +/- 0.01 in controls vs. 0.83 +/- 0.02 in glaucoma patients (P=0.388)OA/PSV: 31.1+/-2.1 in controls vs. 31.1+/-2.2 cms-1 in glaucoma patients (P=0.541)OA/EDV: 3.9 +/- 1.4 in controls vs. 3.7 +/- 1.3 cms-1 in glaucoma patients (P=0.488)OA/RI: 0.88 +/- 0.01 in controls vs. 0.87 +/- 0.01 in glaucoma patients (P=0.86)

Conclusions: : A significant difference of blood flow velocities was seen in the CRA but no difference could be detected in the OA. This implies that blood flow alterations are more pronounced in the smaller vessels and that the measurement of these vessels is of major importance.

Keywords: blood supply • choroid • optic nerve 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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