April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Impact of Body Mass Index on Retrobulbar Flow and Visual Field Damage in Open Angle Glaucoma Patients
Author Affiliations & Notes
  • Meera Ramanathan
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Alon Harris
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Brent A. Siesky
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Mohammadali M. Shoja
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Melanie A. Pickett
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Leslie Abrams
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Darrell WuDunn
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Chi-Wah R. Yung
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • John Abrams
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Yochai Z. Shoshani
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships  Meera Ramanathan, None; Alon Harris, Pfizer (C); Brent A. Siesky, None; Mohammadali M. Shoja, None; Melanie A. Pickett, None; Leslie Abrams, None; Darrell WuDunn, Pfizer (R); Chi-Wah R. Yung, None; John Abrams, None; Yochai Z. Shoshani, None
  • Footnotes
    Support  Unrestricted grant from Research to Prevent Blindness and Pfizer Pharmaceuticals
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6032. doi:
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      Meera Ramanathan, Alon Harris, Brent A. Siesky, Mohammadali M. Shoja, Melanie A. Pickett, Leslie Abrams, Darrell WuDunn, Chi-Wah R. Yung, John Abrams, Yochai Z. Shoshani; The Impact of Body Mass Index on Retrobulbar Flow and Visual Field Damage in Open Angle Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6032.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the impact of body mass index (BMI) on the associations between retrobulbar blood flow and visual field in patients with open angle glaucoma (OAG).

Methods: : 115 patients with OAG (mean age 66.8, 69 female) participating in the Indianapolis Glaucoma Progression Study were divided into three groups based on their body mass index (BMI); normal weight individuals with BMI less than 25 kg/m2 (n = 36), those with BMI of 25-30 kg/m2 (n = 41) and those with BMI > 30 kg/m2 (n = 38). Retrobulbar blood flow velocities and vascular resistance were measured by color Doppler imaging. Visual fields were assessed by Humphrey Visual Field Analyzer using the 24-2 SITA standard program and the American Glaucoma Intervention Study (AGIS) score was determined. Systemic blood pressure was measured using a calibrated automated sphygmomanometer. Spearman rank correlation test was used to estimate the bivariate associations between AGIS score and the retrobulbar vessel flow velocity. Multivariate linear regression analysis (standard method) with rank-transformed data was used to adjust for the effects of age and IOP. P values <0.05 were considered statistically significant.

Results: : Bivariate analysis showed AGIS score to be positively correlated with mean arterial pressure in normal weight OAG patients (r = 0.365, P = 0.029), to be negatively correlated with nasal short posterior ciliary end diastolic velocity (EDV) (r = -0.343, P = 0.030) and temporal short posterior ciliary artery peak systolic velocity (PSV) (r = -0.349, P = 0.025) in OAG patients with BMI of 25-30 kg/m2 and to be weakly negatively associated with temporal short posterior ciliary artery EDV (r=-0.298, P=0.070) and PSV (r=-0.304, P=0.063) in OAG patients with BMI > 30 kg/m2. In multivariate linear regression, these associations were independent of IOP and age.

Conclusions: : Visual field damage in overweight OAG patients is associated with the retrobulbar blood flow. This association was not found in normal weight OAG patients. Our data suggests overweight and obese OAG patients present with different vascular regulation patterns compared to glaucoma patients with normal BMI.

Keywords: blood supply • visual fields • optic disc 
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