Purchase this article with an account.
Meera Ramanathan, Alon Harris, Brent A. Siesky, Mohammadali M. Shoja, Melanie A. Pickett, Leslie Abrams, Darrell WuDunn, Chi-Wah R. Yung, John Abrams, Yochai Z. Shoshani; The Impact of Body Mass Index on Retrobulbar Flow and Visual Field Damage in Open Angle Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6032.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To assess the impact of body mass index (BMI) on the associations between retrobulbar blood flow and visual field in patients with open angle glaucoma (OAG).
115 patients with OAG (mean age 66.8, 69 female) participating in the Indianapolis Glaucoma Progression Study were divided into three groups based on their body mass index (BMI); normal weight individuals with BMI less than 25 kg/m2 (n = 36), those with BMI of 25-30 kg/m2 (n = 41) and those with BMI > 30 kg/m2 (n = 38). Retrobulbar blood flow velocities and vascular resistance were measured by color Doppler imaging. Visual fields were assessed by Humphrey Visual Field Analyzer using the 24-2 SITA standard program and the American Glaucoma Intervention Study (AGIS) score was determined. Systemic blood pressure was measured using a calibrated automated sphygmomanometer. Spearman rank correlation test was used to estimate the bivariate associations between AGIS score and the retrobulbar vessel flow velocity. Multivariate linear regression analysis (standard method) with rank-transformed data was used to adjust for the effects of age and IOP. P values <0.05 were considered statistically significant.
Bivariate analysis showed AGIS score to be positively correlated with mean arterial pressure in normal weight OAG patients (r = 0.365, P = 0.029), to be negatively correlated with nasal short posterior ciliary end diastolic velocity (EDV) (r = -0.343, P = 0.030) and temporal short posterior ciliary artery peak systolic velocity (PSV) (r = -0.349, P = 0.025) in OAG patients with BMI of 25-30 kg/m2 and to be weakly negatively associated with temporal short posterior ciliary artery EDV (r=-0.298, P=0.070) and PSV (r=-0.304, P=0.063) in OAG patients with BMI > 30 kg/m2. In multivariate linear regression, these associations were independent of IOP and age.
Visual field damage in overweight OAG patients is associated with the retrobulbar blood flow. This association was not found in normal weight OAG patients. Our data suggests overweight and obese OAG patients present with different vascular regulation patterns compared to glaucoma patients with normal BMI.
This PDF is available to Subscribers Only