April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Regulation Of Optic Nerve Head Blood Flow During Combined Changes In Intraocular Pressure And Arterial Blood Pressure
Author Affiliations & Notes
  • Agnes Boltz
    Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Doreen Schmidl
    Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Michael Lasta
    Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Semira Kaya
    Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Gabriele Fuchsjaeger-Mayrl
    Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Gerhard Garhofer
    Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Leopold Schmetterer
    Clinical Pharmacology,
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6040. doi:
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      Agnes Boltz, Doreen Schmidl, Michael Lasta, Semira Kaya, Gabriele Fuchsjaeger-Mayrl, Gerhard Garhofer, Leopold Schmetterer; Regulation Of Optic Nerve Head Blood Flow During Combined Changes In Intraocular Pressure And Arterial Blood Pressure. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6040.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : We have previously shown that choroidal blood flow in healthy subjects regulates better during isometric exercise-induced changes in mean arterial blood pressure (MAP) than during suction cup-induced changes in intraocular pressure (IOP). The present study tested the hypothesis that human optic nerve head blood flow (ONHBF) may not only depend on ocular perfusion pressure (OPP), but also on the absolute values of MAP and IOP.

Methods: : Two study days were performed in 20 healthy young subjects. On the first study day the effect of squatting and IOP elevation on ONHBF was investigated separately. On the second study day the effect of combined IOP increase and squatting was studied. IOP was raised in stepwise increments using the suction cup method. ONHBF was measured using laser Doppler flowmetry. OPP was calculated as 2/3*MAP-IOP. For correlation analysis all values from all subjects were pooled according to IOP and MAP values.

Results: : When data were grouped according to MAP values a highly significant correlation was found between ONHBF and IOP (p < 0.001). The correlation between ONHBF and MAP was much less pronounced when data were grouped according to IOP levels (p < 0.05).

Conclusions: : Our data confirm previously published observations that ONHBF shows some autoregulatory capacity during changes in OPP. In addition, our data indicate that ONHBF regulates better during exercise-induced changes in MAP than during a suction cup-induced increase in IOP.

Clinical Trial: : http://www.clinicaltrials.gov NCT00912665

Keywords: blood supply • intraocular pressure • optic disc 
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