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Umit Yolcu, Uzeyir Erdem, Gokcen Gokce, Sami Ozturk, Selim Dagli, Gungor Sobaci; Pupillary function in Atopy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6433.
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Ophthalmic system has been known to be affected by allergic reactions and autonomic imbalance has been proposed as a basis for the abnormalities seen in allergic disorders. There is no ample study identifying the relation between autonomic disfunction and allergic diseases. This study aims to investigate the relationship between pupillary function and atopy.
One hundred and fifty-two atopic subjects (suffering from recurrent allergic conjonctivitis) were compared with 152 age-matched controls (p>0.05) in this study. Photopic and mesopic pupil sizes were measured using OPD-Scan II Pupillometer/Corneal WF Analyser ARK-10000 system (Nidek, Japan). The differences between groups were analyzed by Mann Whitney U- Test.
Photopic and mesopic pupil sizes in allegic patients were significantly higher than control group ( Photopic: 4.88±0.95, 4.50±0.94 mm, p<0.001; Mesopic: 6.31±0.84, 5.85±1.24 mm, p<0.01; respectively).
Autonomic abnormalities or imbalances may be responsable for some clinical manifestations of atopic conjonctivitis. These dysfunctions in atopic patients might play a pathogenic role in alterations in pupillary function.
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