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Elena Zemova, Berna Akova Budak, Berthold Seitz, Nora Szentmary, Achim Langenbucher; The Relationship between Corneal Biomechanical Properties, Endothelial Cell Count and Corneal Pachymetry in Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6446.
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To investigate whether there is a correlation between corneal biomechanical properties, endothelial cell count and corneal pachymetry in healthy subjects.
This prospective study comprised 38 eyes of 38 subjects with normal corneas. All subjects underwent complete ocular examination including intraocular pressure, objective refraction, slitlamp biomicroscopy. Topographic measurements and corneal pachymetry were performed using Scheimpflug-based (Pentacam HR, Oculus, Germany) corneal topographer. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with Ocular Response Analyzer (ORA Reichert Ophthalmic Instruments, Buffalo, NY). Endothelial cell count measurement was done using specular microscope (EM-3000, Tomey, Japan).
Thirty-eight eyes of 38 healthy subjects with a mean age of 29.6±9.4 years (range: 17-55 years) were included in the analysis. Mean corneal hysteresis was 11.3±1.8 mmHg and mean corneal resitance factor was 11.1±0.9 mmHg. The mean endothelial cell count was found to be 2689±212 cells/mm². No correlation was found between biomechanical properties of cornea and endothelial cell count (P>0.05; r=0.22). There was a significant correlation between CH, CRF and corneal thickness (P<0.0001; r =0.75).
The corneal biomechanical properties correlated significantly with corneal thickness. Further studies are required to broaden the knowledge of relationship between corneal biomechanical properties, anterior segment topography and density of endothelial cells.
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