Purchase this article with an account.
Melanie Heinke, Christoph Pohl, Rieke Alten, Carl Erb; Central Corneal Thickness and Endothelial Cell Density in Patients with Rheumatoid Arthritis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6471.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Rheumatoid arthritis (RA) is a systemic, primary inflammatory autoimmune connective tissue disease accompanied by a characteristic polyarticular inflammation. Up to 25% of RA patients exhibit ocular involvement. In about 2% of the cases a primary corneal involvement is found. The study was performed to investigate whether patients suffering from RA exhibit changes in central corneal thickness and endothelial cell density in comparison with a control group as a result of collagen reformation processes.
Thirtyeight patients (male:female=7:31, average age 57.47±5 years) suffering from RA and 41 healthy controls (male:female=10:31, average age 55.24±3.39 years) were included in this study. For selection of patients the classification criteria for RA according to the American College of Rheumatology (ACR) were applied. Inclusion criteria for patients with RA was of a duration of 10 years or more. The following clinical examinations were performed: Visual acuity, slit lamp microscopy of the anterior and posterior segment of the eye, Goldmann applanation tonometry (GAT), central corneal thickness (CCT) with Orbscan II (Bausch & Lomb, USA) as well as endothelial cell density of the cornea with the noncontact specular microscopy (Konan Noncon Robo SP 8000,Konan,Japan).
In all ophthalmological criteria no statistical significant differences could be found, e.g. corneal thickness (RA: 584.95±37,44 µm versus controls:571.81±38.49, p=0.13) and endothelial cell density (RA: 2434.76±384.38 versus controls:2358.89±409.46, p=0.38). In addition, examining the relationship between corneal thickness and cell density, there is a non-significant correlation coefficient of 0.071, which means no significant monotonic relationship is detectable.
Disregarding long duration of the disease (≥10 years), no corneal changes concerning central corneal thickness and endothelial cell density could be found in the rheumatic group. As a consequence these parameters do not require special consideration in future examinations of patients with RA.
This PDF is available to Subscribers Only