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Joseph B. Ciolino, Sarah Hudson, Ashley N. Mobbs, Todd R. Hoare, Gerald R. Fink, Naomi Iwata, Daniel S. Kohane; An Antifungal Contact Lens. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6545.
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To design a contact lens to treat and prevent fungal ocular infections.
Curved contact lenses were created by encapsulating econazole-impregnated PLGA (poly[lactic-co-glycolic acid]) films in pHEMA (poly[hydroxyethyl methacrylate]) using ultraviolet photopolymerization. Release studies were conducted in phosphate buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross-sections of the pre-release and post-release contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.
Econazole-eluting contact lenses provided extended antifungal activity (over 3 weeks) against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens (Figure 1).
An econazole eluting contact lens could potentially be used as a treatment for fungal ocular infections.
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