March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Effect Of Topical Carbonic Anhydrase Inhibitors vs. The Combination Of Topical And Systemic Carbonic Anhydrase Inhibitors In The Treatment Of Primary Glaucoma In Dogs
Author Affiliations & Notes
  • Elizabeth A. Laminack
    Companion Animal Hospital, Athens, Georgia
  • Kathern E. Myrna
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia
  • Phillip A. Moore
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia
  • Footnotes
    Commercial Relationships  Elizabeth A. Laminack, None; Kathern E. Myrna, None; Phillip A. Moore, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5013. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Elizabeth A. Laminack, Kathern E. Myrna, Phillip A. Moore; The Effect Of Topical Carbonic Anhydrase Inhibitors vs. The Combination Of Topical And Systemic Carbonic Anhydrase Inhibitors In The Treatment Of Primary Glaucoma In Dogs. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5013. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To determine if there is a benefit to combining topical and systemic carbonic anhydrase inhibitors (CAI) to treat primary glaucoma in dogs.

Methods: : The medical records of the UGA-VTH were searched from 2005-2010 for dogs with primary glaucoma (narrowed or closed angle). Patients were divided into three groups: topical 2% dorzolamide alone; oral methazolamide alone; or combination therapy. Eyes were categorized as initially affected (increased IOP) or contralateral (predisposed to increased IOP). Significance was defined as p<0.05. Changes in IOP over time were compared by repeated measures analysis. Systemic and ocular side effects were compared by chi-square test.

Results: : 30 medical records met the search criteria: topical CAI alone (patients N=20; eyes N=34); oral CAI alone (patients N=6; eyes N=6) and combination (patients N=10; eyes N=15). The average follow up was 168 days. The probability of disease control was not significantly different between groups. The average time to treatment failure in the initial eye was 37 days. The average time to the onset of glaucoma in the contralateral eye was 196 days. The addition of prostaglandin analogs and/or timolol to the treatment scheme was not associated with the overall treatment success between groups. When both eyes are considered, the addition of prostaglandin analogs significantly (travoprost p<0.01, latanoprost p<0.002) lowered the IOP in all three groups. There was no significant difference in the incidence of systemic or ocular side effects between groups.

Conclusions: : Combination therapy of oral and topical CAI is not associated with increased side effects but has no benefit when compared to oral or topical use alone for the treatment of primary glaucoma in dogs.

Keywords: carbonic anhydrase • drug toxicity/drug effects 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×