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Monica Jong, RIchard Norman, Christopher Hudson, Ayda M. Shahidi, Shaun Singer, John G. Flanagan; Diurnal Change in Choroidal Thickness, Intraocular Pressure and Blood Pressure. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5046.
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A preliminary study to investigate diurnal change in choroidal thickness and its relationship to intraocular pressure (IOP), axial length (AL), and blood pressure (BP).
The sample consisted of 3 healthy participants (mean age 27.7 ± 0.6 years) with refractive error less than ± 6.00 D sphere and/or ± 2.50 D cylinder, no ocular or systemic diseases and no medications. Measurements of choroidal thickness (Spectralis SD-OCT; Heidelberg Engineering), axial length (IOLMaster; Carl Zeiss Meditec), intraocular pressure and blood pressure, were recorded every 2 hours between 8am and 8pm. SD-OCT imaging used the standard macular volume scan protocol (1, 3, 6 mm ETDRS, 25 X 25) and RNFL thickness scan protocol. Choroidal thickness maps were produced for the macular and peripapillary regions. Three measurements were averaged for each time point.
Diurnal variation was observed in all parameters. Over 12 hours the mean percentage variation in: peripapillary choroidal thickness was 10.0 ± 2.6%; foveal choroidal thickness was 15.0 ± 3.4%; IOP was 14.3%; systolic BP was 12.8 ± 2.9%(p= 0.48); diastolic BP was 16.8 ± 1.5%; axial length was 0.29 ± 0.21%; ocular perfusion pressure was 18.3 ± 3.5%. No significant correlation was observed between parameters. However, an antiphase relationship between foveal and peripapillary choroidal thickness was observed.
Choroidal thickness, IOP, BP and axial length, all demonstrated diurnal change, but did not appear to co-vary using a simple linear model.
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