Abstract
Purpose: :
To investigate the 24-hour effects of bimatoprost 0.01% monotherapy on intraocular pressure (IOP) and ocular perfusion pressure (OPP).
Methods: :
This was a prospective, open-label experimental study. Baseline data of 24-hour IOP in untreated patients were collected in a sleep laboratory. Measurements of IOP were taken using a pneumatonometer every 2 hours in the sitting and supine body positions during the 16-hour diurnal/wake period and in the supine position during the 8-hour nocturnal/sleep period. After baseline measurements were taken, patients were treated with bimatoprost 0.01% one time per day at bedtime for 4 weeks, then 24-hour IOP data were collected under the same laboratory conditions. Diurnal and nocturnal IOP and OPP means under bimatoprost 0.01% treatment were compared with baseline.
Results: :
Sixteen patients with diagnosed primary open-angle glaucoma (POAG) or ocular hypertension (ages, 49-77 years) were included in the study. The diurnal and nocturnal IOP means were significantly lower under the bimatoprost 0.01% treatment than baseline in both the sitting and supine positions. The diurnal and nocturnal OPP means were significantly higher under treatment than baseline in both the sitting and supine positions.
Conclusions: :
Bimatoprost 0.01% monotherapy significantly lowered IOP and increased OPP during the 24-hour period.
Clinical Trial: :
http://www.clinicaltrials.gov NCT01271686
Keywords: intraocular pressure • optic flow • circadian rhythms