Purchase this article with an account.
Anastasios-Georgios P. Konstas, Luciano Quaranta, Theodoros Giannopoulos, Ivano Riva, Andreas Katsanos, Irini C. Voudouragkaki, Eleni Paschalinou, Irene Floriani, Anna-Bettina Haidich; Comparison of 24-hour efficacy with Tafluprost compared with Latanoprost in patients with Primary Open-Angle glaucoma or Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5104.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare the 24-hour intraocular pressure (IOP) control obtained with preservative-free tafluprost to preservative-containing latanoprost when both are administered as first choice therapy in patients with primary open-angle glaucoma (POAG), or ocular hypertension (OHT).
Prospective, observer-masked, crossover comparison. The study included consecutive, newly-diagnosed patients with POAG, or OHT and baseline IOP between 24-33 mm Hg. All patients underwent a baseline untreated 24-hour IOP curve measured in habitual positions, with Goldmann sitting tonometry at 10:00, 14:00, 18:00, 22:00 and Perkins supine tonometry at 02:00 and 06:00. They were then randomized to either latanoprost, or tafluprost administered in the evening for 3 months and then switched to the opposite therapy for another 3 months. At the end of each treatment period patients underwent a 24-hour IOP evaluation.
Thirty-eight patients with POAG or OHT completed the study. The mean untreated 24-hour IOP (24.9 mm Hg) was significantly reduced with both prostaglandin analogues (P<0.001). When the two drugs were compared directly, tafluprost demonstrated similar mean 24-hour efficacy compared with latanoprost (17.8 vs 17.7 mm Hg, P=0.417). A small, non-significant efficacy superiority of latanoprost during the period between 10:00-18:00 (0.4-0.5 mm Hg) reversed during the period between 22:00-06:00 (-0.2-0.4 mm Hg). Latanoprost provided significantly better 24-hour trough IOP (15.9 vs 16.3 mm Hg, P=0.041), whereas tafluprost provided significantly lower 24-hour IOP fluctuation (3.21 vs 3.84 mm Hg, P=0.008). No significant difference existed between the two prostaglandins for any adverse event.
In this crossover study, preservative-free tafluprost employed as first choice therapy achieved statistically similar 24-hour IOP reduction when compared to latanoprost. The mean 24-hour difference between the two prostaglandins was 0.1 mm Hg. The current study highlights the importance of complete assessment of efficacy over 24 hours.
Clinical Trial: :
This PDF is available to Subscribers Only