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ryo terao, yasuo yanagi, ryo obata; Efficiency of anti-VEGF Therapy for Age-Related Macular Degeneration; Comparison between Phakic and Pseudophakic groups. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5163.
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Several laboratory studies suggest that there is an association between cataract surgery and age-related macular degeneration (AMD). The current study was performed to evaluate the relation between state of crystalline lens (phakia or pseudophakia) and the one year efficiency of anti vascular endothelial growth factor (VEGF) therapy for subfoveal choroidal neovascularization (CNV) secondary to AMD in Japanese patients.
This retrospective case study that included 132 eyes of 127 patients with CNV secondary to AMD. Each of the patients was classified by the state of lens (phakia or pseudophakia). All patients received three monthly dosing of ranibizumab, which was followed by monthly PRN dosing regimen. Best-corrected visual acuity (BCVA) performed by a standard Japanese decimal visual acuity chart and converted to logMAR for statistical analysis, and central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography (SD-OCT) for 12 months.
Phakia group contained 99 eyes of 97 patients (54 - 87 years old), pseudophakia group contained 33 eyes of 32 patients (63 - 90 years old). Baseline BCVA was 0.43±0.35 logMAR in the phakia group and 0.42±0.44 logMAR in the pseudophakia group, and baseline CRT was 317±167μm in the phakia group and 325±129μm in the pseudophakia group, with no statistical difference between the two groups (P=0.646 and 0.853, respectively). Mean change of BCVA at 3, 6, 9 and 12 months were -0.12±0.22 , -0.088±0.26, -0.088±0.28 and -0.088±0.29 logMAR in the phakia group and -0.063±0.17, -0.021±0.20, 0.00012±0.29 and 0.0083±0.27 logMAR in the pseudophakia group. Mean change of CRT at 3, 6, 9 and 12 months were -88.1±141 ,-122±166, -98.8±155 and -93.2±146μm in the phakia group and -103±0.71, -90.8±115, -52.9±160 and 83.5±197μm in the pseudophakia group. There were no statistically significant differences between the groups. None patients underwent intraocular operation, including caratact surgery during observation.
State of lens was not associated with visual and anatomical prognosis for anti-VEGF therapy for CNV secondary to AMD.
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