Abstract
Purpose: :
At present time, there is a growth of incidence of retinal venous and arterial occlusions among population of young-to-mid age, resulted from defects at different levels of haemostatic system or hemorheology. Purpose of this work was to study haemostatic parameters in patients with retinal vein or artery occlusion.
Methods: :
Study included 100 patients, aged 18-52 years: 80 had monolateral retinal vein occlusion and 20 had monolateral retinal artery occlusion. Haemostatic factors were measured using automated coagulation analyzer ACL200 (Instrumentation Laboratory, USA), semi-automated coagulometer (Behnk Elektronik, Germany), and standard sets of reagents (Instrumentation Laboratory, USA; Dade Behring, Siemens USA).
Results: :
Hyperaggregation of platelets with ADP-collagen, ristomycin and adrenaline was found in 35%. Increased activity of Villebrand’s factor was found in 32%. Lupus anticoagulant was found in 15%. Hyperhomocystinemia, mutation of factor V (Leiden’s) in combination with lupus anticoagulant were found in 11%. Level of soluble fibrin-monomer complexes was increased in 7% of patients with retinal vein occlusions. Activated partial thromboplastine time and fibrinogen level did not show significant changes.
Conclusions: :
89% of patients with retinal artery and vein occlusions revealed thrombocytic, plasma-coagulative and vascular forms of thrombophilias. 11% patients with retinal vein occlusion showed combined defects in the haemostatic system (hyperhomocystinemia, mutation of factor V (Leiden’s), lupus anticoagulant). Our findings should be taken into account when choosing therapeutic strategy for patients with occlusions of retinal vessels.
Keywords: retina • vascular occlusion/vascular occlusive disease • pathology: human