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Carol L. Karp, Anat Galor, Patrick Oellers, Andrew Kao, Amany Abdelaziz, William Feuer, Sander Dubovy; Predictors Of Ocular Surface Squamous Neoplasia Recurrence After Exisional Surgery. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5611.
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© ARVO (1962-2015); The Authors (2016-present)
To identify predictors of ocular surface squamous neoplasm (OSSN) recurrence after surgical resection.
Review of pathology records and patient charts of 389 consecutive OSSN lesions excised at the Bascom Palmer Eye Institute from January 1, 2001, to September 20, 2010
Of 389 completely excised OSSN lesions, forty-four (11%) recurred during follow up. The 1 year recurrence rate was 10% and the 5 year recurrence rate was 21%with a mean time to recurrence in those with a recurrence of 2.5 years (SD 3.4). Location characteristics that increased the risk of tumor recurrence were tarsal involvement (HR=4.12, p = 0.007). Nasal locations were associated with a decreased risk of tumor recurrence (HR=0.41, p=0.008). Pathologic characteristics significantly associated with tumor recurrence were the presence of positive margins (HR=2.73, p= 0.008). Treatment with adjuvant cryotherapy significantly decreased the risk of tumor recurrence (HR=0.51, p=0.03). In those patients with positive margins, the use of post-operative topical interferon therapy lowered the recurrence rate to a level similar to that of patients with negative margins.
Certain patient and tumor factors are associated with a higher risk of OSSN recurrence after surgical excision. Post-operative adjuvant therapy should be considered in patients with high risk OSSN characteristics, including tarsal tumor location and positive surgical margins.
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