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Dong Ho Park, In Taek Kim; Polymorphism in Vascular Endothelial Growth Factor and Its Receptor Genes in Polypoidal Choroidal Vasculopathy in a Korean Population. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5645.
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To investigate whether polymorphisms in vascular endothelial growth factor A (VEGF-A) and VEGF receptor-2 (KDR) genes are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and whether they are associated with phenotypes of PCV.
This is a case-control study comprised of 111 patients with PCV and 123 control subjects. The PCV and control groups were genotyped for 5 polymorphisms in VEGF-A and 1 polymorphism in KDR genes. Clinical characteristics were evaluated including best-corrected visual acuity, fundus findings, and angiographic findings at first visit. Main outcome measures were the genotypes of the variants and association with the phenotypes.
Only rs833069 in VEGF-A generated significant allelic associations with PCV (P = 2.24x10-5). The GG genotype group in rs833069 had a 6.25-fold increased risk (P = 7.45x10-5; 95% confidence interval [CI], 2.52-15.46) and AG group had a 1.82-fold increased risk of PCV (P = 0.029; 95% CI, 1.03-3.24) compared to AA group, respectively. The haplotype (CCGC) in VEGF-A showed an association with PCV (P = 2.90x10-5). However, phenotypic characteristics of PCV did not show an association with the rs833069 genotypes.
The rs833069 polymorphism in VEGF-A is significantly associated with the risk of PCV in a Korean population.
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