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Bo Lei, Hui Peng, Juanping Yin, Qiuhong Li; The Characteristics Of Cone-driven Oscillatory Potentials In Human Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5703.
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© ARVO (1962-2015); The Authors (2016-present)
The most important visual information in human beings is ferried by the cone system. Nowadays, electroretinogram (ERG) is an indispensable and objective means to detect retinal functions. ERG oscillatory potentials (OPs) are indicators of the inner retinal function. However, only mixed-OPs driven by cones and rods are used in clinical service and research. Very little is known about the cone-driven OPs. We characterized cone-driven OPs in human subjects.
Dark- and light-adapted ERGs of nineteen normal eyes recorded from 10 consecutive cases aged 22 to 29 were studied. The frequency spectra of extracted cone-driven OPs and mixed OPs were analyzed by a fast Fourier transform. The peak frequency, implied time and the total power of the OPs were determined. Mann Whitney test was applied to determine where there were significance between the cone-driven and the mix OPs.
The averaged peak frequencies of the cone-driven and the mix OPs were 80.3 ± 6.3Hz (mean ± standard deviation, 95% confidence interval CI: 77.2 ~ 83.5) and 123.4 ± 9.1Hz (95% CI: 119.0 ~ 127.8) respectively. The peak frequency of cone-driven OPs was significantly lower than that of the mixed OPs (p <0.0001). The averaged implicit time of the cone-driven OP (40.3 ± 3.8ms, 95% CI 38.5 ~ 42.1) was significantly longer (p <0.0001) than that of the mixed-OP (27.6 ± 2.9ms, 95% CI: 26.2 ~ 29.0). The averaged power of the cone-driven OPs (8.3 ± 4.8 (uV * s) 2, 95% CI 6.0 ~ 10.6) was significantly smaller (p = 0.0003) than that of the mixed-OPs (3.4 ± 2.2 (uV * s) 2, 95% CI: 2.3 ~ 4.5). The cone-driven OPs accounted for 41% of the mixed OPs.
Being integrated parts of ERG, the cone-driven OPs in human share many similar features with cone-driven OPs in mice, in terms of peak frequency, implicit time and power (Lei et al., IOVS, 2006). However, the proportion of the power of cone-driven OPs in the total mixed OPs in human is much greater than that in mice, implying cone-driven OPs play more important role in signal processing in human. Understanding the features of the cone-driven OPs is essential for further utilization.
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