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Mohd I. Nawaz, Mohammad S. Ola, Mohammed M. Siddiquei, Karel Geboes, Ahmed A. El-Asrar; Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5756.
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© ARVO (1962-2015); The Authors (2016-present)
To determine levels of angiogenic and endothelial progenitor cell mobilizing (vasculogenic) factors in vitreous fluid from proliferative diabetic retinopathy (PDR) patients and correlate their levels with clinical disease activity.
Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), stem cell factor (SCF), soluble c-kit (s-kit) and prostaglandin E2 (PGE2) levels were measured by ELISA in vitreous samples from 34 PDR and 15 nondiabetic patients.
VEGF, sVEGFR-2, SCF, and s-kit levels and mean VEGF to sVEGFR-2 ratio were significantly higher in PDR with active neovascularization compared with quiescent PDR and nondiabetic patients (p<0.001; 0.007; 0.001; <0.001; 0.0103, respectively). VEGF, sVEGFR-2, SCF and s-kit levels and mean VEGF to sVEGFR-2 ratio were significantly higher in PDR with hemorrhage compared with PDR without hemorrhage and nondiabetic patients (p<0.001; 0.003; 0.001; 0.001; 0.0181, respectively). PGE2 levels were significantly higher in nondiabetic patients compared with PDR patients (p<0.001). There were significant correlations between levels of sVEGFR-2 versus SCF (r=0.950, p<0.001), sVEGFR-2 versus s-kit (r=0.941, p<0.001) and SCF versus s-kit (r=0.970, p<0.001).
Upregulation of VEGF, sVEGFR-2, SCF and s-kit supports the contributions of angiogenesis and vasculogenesis in pathogenesis of PDR.
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