March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Endothelial Graft Failure after Contralateral Autologous Corneal Transplantation
Author Affiliations & Notes
  • Jaime D. Martinez
    Bascom Palmer Eye Institute, Miami, Florida
  • Anat Galor
    Bascom Palmer Eye Institute, Miami, Florida
  • Victor L. Perez
    Bascom Palmer Eye Institute, Miami, Florida
  • Carol L. Karp
    Bascom Palmer Eye Institute, Miami, Florida
  • Sonia H. Yoo
    Bascom Palmer Eye Institute, Miami, Florida
  • Eduardo C. Alfonso
    Bascom Palmer Eye Institute, Miami, Florida
  • Footnotes
    Commercial Relationships  Jaime D. Martinez, None; Anat Galor, None; Victor L. Perez, None; Carol L. Karp, None; Sonia H. Yoo, None; Eduardo C. Alfonso, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6047. doi:
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      Jaime D. Martinez, Anat Galor, Victor L. Perez, Carol L. Karp, Sonia H. Yoo, Eduardo C. Alfonso; Endothelial Graft Failure after Contralateral Autologous Corneal Transplantation. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6047.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report on outcomes after contralateral autologous penetrating keratoplasty (APK)

Results: : We report on 5 patients who underwent contralateral APK. The median patient age at the time of surgery was 67 years (range, 58-88 years); 4 patients were male and 1 female, 1 patient was white and 4 black. The surgery was uneventful in all cases and no operative or immediate post-operative complications occurred in either eye. Follow-up time ranged from 18-54 months (mean, 34.6 months; median, 20 months). During this time, 4 of the autologous grafts failed due to endothelial attenuation as opposed to none of the 5 allogeneic grafts in the donor eye. Identified risk factors for failure in the autologous eyes included the presence of a glaucoma tube (5/5), previous graft failure (4/5) and anterior synechiae in (2/5).

Conclusions: : This study is the first to describe graft failure due to slow endothelial attenuation after APK. This study underscores the importance of non-immunologic factors in endothelial cell loss after corneal transplant surgery and highlights the need for further research to understand and modulate endothelial loss.

Keywords: cornea: endothelium • cornea: clinical science 
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