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Daniel Tilia, Percy Lazon De La Jara, Nikki Peng, Hua Zhu, Mark D. Willcox, Brien A. Holden; Comparison Of Two Dual-disinfection Systems For Ocular Comfort, Corneal Staining And Corneal Infiltrative Events. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6090.
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© ARVO (1962-2015); The Authors (2016-present)
To retrospectively compare ocular comfort ratings, corneal staining, and the incidence of solution induced corneal staining (SICS) and corneal infiltrative event (CIE) between two lens care products (LCPs) when used with a silicone hydrogel contact lens
Ocular comfort ratings and corneal staining, SICS and CIE incidence were extracted retrospectively from two prospective, unmasked studies involving 79 participants wearing balafilcon A (PureVision®, Bausch + Lomb, USA) and using one of two LCPs; RevitaLens OcuTec® multipurpose disinfecting solution (MPDS) (alexidine dihydrochloride and polyquaternium-1, Abbott Medical Optics, Inc. USA) or Biotrue™ multipurpose solution (MPS) (PHMB and polyquaternium-1, Bausch + Lomb, USA). Each study followed the same protocol Visits were at baseline, two weeks, one month and three months. Comfort (1-10 scale) and corneal staining (0-4 grade) were compared between LCPs using linear mixed model. SICS and CIEs were reported as the first occurrence per 100 participant-months for each LCP and compared using Fisher’s exact test and mid-p test for incidence rates
There were no significant differences between RevitaLens OcuTec MPDS and Biotrue MPS for comfort on insertion (7.6±1.6 v 8.0±1.5, p>0.05), comfort during the day (8.1±1.4 v 7.8±1.5, p>0.05) or end of the day comfort (7.0±1.7 v 6.8±1.7, p>0.05). Corneal staining was significantly less with RevitaLens OcuTec compared to Biotrue (0.7±0.6 v 1.8±0.8, p<0.001). SICS incidence was also significantly lower with RevitaLens OcuTec compared to Biotrue (5.1% v 29.0%, p<0.001), while there was no significant difference between LCPs for CIE incidence (0 v 1.8%, p>0.05).
The PHMB/polyquat containing Biotrue MPS produced more SICS than the alexidine/polyquat containing RevitaLens OcuTec MPDS. Similar ocular comfort observed between the LCPs might be due to using the same contact lens type and the low CIE incidence indicates both LCPs are effective in controlling lens/case contamination.
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