March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Morning Cleaning or Replacement of Lenses Reduces Complications with Extended Wear of Contact Lenses
Author Affiliations & Notes
  • Jerome Ozkan
    Clinical Research & Trials Centre,
    Brien Holden Vision Institute, Sydney, Australia
  • Mark D. Willcox
    Brien Holden Vision Institute, Univ of New South Wales, Sydney, Australia
  • Percy Lazon De La Jara
    Brien Holden Vision Institute, Sydney, Australia
  • Varsha M. Rathi
    Cornea, Contact lens, Refractive Surgery, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India
  • Brien A. Holden
    Brien Holden Vision Institute, Vision Cooperative Research Centre, Sydney, Australia
  • Footnotes
    Commercial Relationships  Jerome Ozkan, None; Mark D. Willcox, None; Percy Lazon De La Jara, None; Varsha M. Rathi, None; Brien A. Holden, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6092. doi:
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      Jerome Ozkan, Mark D. Willcox, Percy Lazon De La Jara, Varsha M. Rathi, Brien A. Holden; Morning Cleaning or Replacement of Lenses Reduces Complications with Extended Wear of Contact Lenses. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6092. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : A previous study has shown that the rate of microbial keratitis is comparable to the rate corneal erosions coupled with gram negative contamination of lenses. A retrospective analysis was conducted to determine if cleaning or replacing lenses in the morning or evening, during continuous wear, influenced the rate of corneal erosions.

Methods: : Previously conducted continuous wear studies at the same site consisted of: morning lens replacement study (n=87) and evening lens replacement study (n=90) where subjects discarded worn lenses and replaced with a new lens each morning or night, respectively; morning lens cleaning study (n=100) where subjects removed and cleaned lenses with a commercial multipurpose solution (COMPLETE® Easy Rub™, Abbott Medical Optics, USA) and immediately reinserted the lenses. The historical control was monthly lens replacement (n = 95) where lenses were worn for one month and then discarded. All subjects were dispensed with silicone hydrogel lenses (lotrafilcon A, CIBA VISION, USA) on a 30-night overnight wear schedule. Clinic visits were conducted at 1 week, 1 month and 3 months.

Results: : Logistic regression analysis showed a reduced risk of mechanical events (corneal erosion, superior epithelial arcuate lesion, contact lens papillary conjunctivitis) with morning lens replacement (0.8%, p = 0.013 [1 month]) and morning lens cleaning (1.0%, p = 0.031 [1 month] and p = 0.042 [3 months]) compared to nightly lens replacement (3.4%) and monthly lens replacement (5.2%). These mechanical events were driven primarily by corneal erosions, the incidence of which was 0.6% for morning lens replacement, 0.5% for morning lens cleaning, 3.4% for nightly lens replacement and 3.1% for monthly lens replacement.

Conclusions: : Continuous contact lens wear related ocular mechanical adverse events can be reduced by changes in cleaning or replacement modality and such changes may be related to elimination of the overnight ‘debris accumulation’ with a morning replacement / cleaning modality.

Clinical Trial: : ACTRN12610000336088

Keywords: contact lens • clinical (human) or epidemiologic studies: outcomes/complications 

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