March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Contact Lens/Contact Lens solution Combinations Determine the Inflammatory Changes on the Ocular Surface: A Laser In Vivo Confocal Microscopy Study
Author Affiliations & Notes
  • Bernardo M. Cavalcanti
    Cornea/Ophthalmology, Harvard Medical School/MEEI, Boston, Massachusetts
  • Andrea Cruzat
    Cornea / Ophthalmology, Harvard Medical Sch/MEEI, Boston, Massachusetts
  • Yureeda Qazi
    Ophthalmology, Contact Lens,
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Neda Baniasadi
    Cornea/Ophthalmology, MA Eye & Ear Infirm/Harvard Med Sch, Boston, Massachusetts
  • Monique Trinidad
    Cornea Research, Ophthalmology,
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Amy Watts
    Contact Lens,
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Douglas Critser
    Ophthalmology, Contact Lens,
    University of Iowa, Iowa City, Iowa
  • Charles Leahy
    Contact Lens,
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Christine W. Sindt
    Cornea Research, Ophthalmology,
    University of Iowa, Iowa City, Iowa
  • Pedram Hamrah
    Cornea/Ophthalmology, Harvard Medical School/MEEI, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  Bernardo M. Cavalcanti, None; Andrea Cruzat, None; Yureeda Qazi, None; Neda Baniasadi, None; Monique Trinidad, None; Amy Watts, Alcon (F); Douglas Critser, None; Charles Leahy, Alcon (F); Christine W. Sindt, Alcon (F); Pedram Hamrah, Alcon (F)
  • Footnotes
    Support  NIH K08-EY020575, New England Corneal Transplant Research Fund, Falk Medical Research Trust, Alcon Research LTD.
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6112. doi:
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      Bernardo M. Cavalcanti, Andrea Cruzat, Yureeda Qazi, Neda Baniasadi, Monique Trinidad, Amy Watts, Douglas Critser, Charles Leahy, Christine W. Sindt, Pedram Hamrah; Contact Lens/Contact Lens solution Combinations Determine the Inflammatory Changes on the Ocular Surface: A Laser In Vivo Confocal Microscopy Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6112.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the subclinical immune responses to various contact lenses (CL) and CL solutions in naive CL wearers.

Methods: : Multicenter, randomized, double-blinded, clinical trial. Sixty-five naïve CL wearers (130 eyes), fitted with silicone hydrogel CL (PureVision® [PV]; Oasys® [OA]; Biofinity® [BF]), were enrolled into one of 3 CL solution groups (OPTI-FREE RepleniSH® (OF, n=21); Clear Care® (CC, n=21); ReNu MultiPlus® (RM, n=23). Corneal, limbal, and conjunctival staining, ocular injection, as well as laser in vivo confocal microscopy (IVCM; HRT3/RCM) of the central and peripheral corneal quadrants were performed at baseline and weeks 1 and 6 post-CL wear. Three masked observers analyzed the images for dendritic cell (DC) and non-dendritic inflammatory cell (IC) density.

Results: : Increased ocular surface staining, but minimal ocular injection was observed in all groups. Conjunctival staining correlated to peripheral DC density (r>0.40 for all quadrants). RM demonstrated significantly increased staining for all conjunctival, limbal and cornea areas, correlating with highest increase in DC density in central cornea (58%), nasal (26%) and temporal (24%) quadrants at 6 weeks, as compared to OF and CC (p<0.05 between groups). Comparison of CL types showed significantly increased limbal and corneal staining for OA (p<0.05) and corneal staining with PV (p<0.04), but minimal staining with BF, with OA demonstrating highest increase in total DC (27%) as compared to PV (13%) and BF (12%) (p<0.05 between groups). Surprisingly, each CL and CL solution demonstrated combinations with minimal surface staining and no significant increase in DC as well as combinations with significant increase staining, with increase in peripheral DC.

Conclusions: : IVCM revealed increased immune cell infiltration in all groups after CL wear as early as 1 week, while corneal and conjunctival staining were detected later at 6 weeks. While our data demonstrates that increased ocular surface staining and immune cell density are both due to CL and CL solutions, proper combination will both prevent or worsen staining and subclinical increase in immune cells.

Clinical Trial: : http://www.clinicaltrials.gov NCT01250925

Keywords: imaging/image analysis: clinical • inflammation • contact lens 
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