March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Treatment of Numular Keratitis with Intracorneal Gancyclovir
Author Affiliations & Notes
  • Eduardo Arenas
    ophthalmology, Santa Fe Foundation, BOGOTA, Colombia
  • Alexandra Mieth
    Asocornea, Bogota, Colombia
  • Footnotes
    Commercial Relationships  Eduardo Arenas, None; Alexandra Mieth, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6205. doi:
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      Eduardo Arenas, Alexandra Mieth; Treatment of Numular Keratitis with Intracorneal Gancyclovir. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6205.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To introduce a new and effective treatment for the management of nummular keratitis using intracorneal depot injections of gancyclovir. After more than 10 years of experience with the use of intracorneal injections for the treatment of different corneal inflammatory diseases

Methods: : Once the diagnosis was confirmed by the typical nummular clinical appearance of the sub epithelial round spots , patients were injected with a mixture of Bethametasone depot and gancyclovir, under the Bowman's layer . Injections were placed close to the area with maximum inflammation and the amount of medication established by us was 0.01 cc. Any other type of medication was stopped and the patients were observed weekly. Doses were repeated if after two weeks the clinical picture has not disappeared completely

Results: : Thirteen cases were treated 10 women and three males . All the cases showed a marked improvement of the signs and symptoms after the first injection. In five cases most of them recurrent keratitis it was necessary to place 5 injections,in three cases 3 injections , two cases 2 doses and in two cases the clinical picture disappeared after the first injection. Eight cases were asymptomatic after one month two after 2 months and in three I took more than three months for the disappearance of the signs and symptoms. No side effects were observed in this series of cases.

Conclusions: : The use of intracorneal injections of a mixture of bethametasone and gancyclovir is a It safe and effective new way for the treatment of acute and chronic nummular keratitis

Keywords: adenovirus • keratitis • injection 

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