Clinical utility of Ophthalmic Antimicrobial Susceptibility Measurement Plate

Abstract

 

Purpose:

 

To evaluate the clinical utility of SG17 (Ophthalmic Antimicrobial Susceptibility Measurement Plate:Fig1), newly developed plate to measure the minimum inhibitory concentration (MIC) for bacterial isolates of ocular infection.

 

Methods:

 

Antimicrobial susceptibility was measured using 96 strains detected from 78 patients diagnosed as ocular infection in five institutes. The clinical utility of SG17 was evaluated to compare MIC measured by SG17 to susceptibility measured by routine method at each institute.

 

Results:

 

Of the 96 strains, 85(88.5%) were gram positive strains, those of 34(35.4%) were coagulase-negative Staphylococci, 22(22.9%) were Corynebacterium spp. and 15(15.6%) were Staphylococcus aureus. SG17 measured MIC up to higher concentration actually used for topical treatment at ocular surface than systemic treatment. MIC90 of each strain was showed in Table 1. The 78 patients received one or more drugs among 11 antimicrobial eye drops or ointment. The rate that can measure the susceptibility of actually used drugs was 100% in SG17 and30.8% in routine method at each institute. In 54(69.2%) patients, the clinical utility of SG17 was better than that of routine method at each institute.

 

Conclusions:

 

These results suggest that SG17 can measure the drug susceptibility of antimicrobial eye drops and it is useful for the treatment of ocular infection.  

 

Keywords: antibiotics/antifungals/antiparasitics • bacterial disease • keratitis