Abstract
Purpose: :
The relationship among body fat distribution, serum leptin levels, and high-sensitive CRP (hsCRP) levels was investigated in patients with age-related macula degeneration in comparison to patients with a normal fundus.
Methods: :
100 patients were included in this case-control study. Body weight (BW) and height (BH), and body mass index (BMI) were measured for each subject. Body composition and abdominal fat areas were measured using dual-energy X-ray absorptiometry. Data on age, gender distribution, smoking history, and systemic diseases, respectively, were compared.The serum leptin and hsCRP levels were assayed by ELISA (R&D) in 54patients with exudative AMD and compared to 46 gender- and age-matched healthy control subjects.The association between the exudative AMD and serum leptin and hsCRP level were examined using a chi(2) test and logistic regression.
Results: :
Dual-energy X-ray absorptiometry revealed central-abdominal-to-total body fat ratio of 0.085+/- 0.02 in AMD patients compared 0.074+/- 0.02 in the healthy controls (p=0.03). Serum leptin level was significantly higher (p < 0.01) in AMD compared to controls. Values for hsCRP were 4.8 ± 0.6 mg/L and 3.2 ± 0.3 mg/L in AMD and controls, respectively.
Conclusions: :
Our results suggest that abdominal fat distribution, but not whole body fat mass, are associated with age-related macular degeneration in men and women. Analysis of patients with exudative AMD revealed higher levels of serum leptin and hsCRP in patients with exudative age-related macular degeneration.
Clinical Trial: :
http://www.clinicaltrials.gov NCT 00533754
Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: risk factor assessment • inflammation