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Pinio Matoula, Kouris Ninios, Nora Szentmary, Rima Obeid, Berthold Seitz; Plasma Homocysteine And Extracellular Soluble Receptor For Advanced Glycation End Products (esRage) In Aqueous Humor Of Patients With Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6517.
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To investigate a possible association between blood concentrations of total homocysteine (tHcy) and aqueous humor concentrations of extracellular soluble receptor for advanced glycated end products (esRAGE) with age-related macular degeneration (AMD).
We examined patients with dry (n = 38) and wet AMD (n = 31). Diagnosis was confirmed by funduscopy, optical coherence tomography and fluorescein angiography. Controls were patients with senile cataract (n = 48). Concentrations of tHcy, its metabolic products and vitamin B markers were measured in blood of 117 patients. Aqueous humor concentrations of esRAGE were measured in 77 patients.
Mean concentrations of plasma tHcy and aqueous humor esRAGE did not differ significantly between the groups. A significant negative correlation was found in controls between tHcy and esRAGE (r = -0.483, p = 0.006).
Our study found no significant difference in esRAGE and tHcy concentrations between AMD patients and controls. Our outcomes could not support the protective role of B-vitamins from AMD. Further studies are needed to investigate the role of B-vitamins in age-related eye diseases.
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