March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Intraocular Pressure Response in Glaucoma Patients Using Difluprednate 0.5% Post Operatively after Phacoemulsification
Author Affiliations & Notes
  • Melissa M. Cable
    Discover Vision Centers, Independence, Missouri
  • Footnotes
    Commercial Relationships  Melissa M. Cable, alcon (C, R), bausch and lomb (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6697. doi:
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    • Get Citation

      Melissa M. Cable; Intraocular Pressure Response in Glaucoma Patients Using Difluprednate 0.5% Post Operatively after Phacoemulsification. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6697.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To report rates of intraocular pressure spikes in open angle glaucoma patients undergoing uncomplicated phacoemulsification surgery using difluprednate ophthalmic emulsion 0.05% qd postoperatively.

Methods: : Retrospective chart review using electronic health records was used for 24 patients who had a diagnosis of open angle glaucoma but were not known steroid responders and who were currently using pressure lowering medications, had undergone slt or both.

Results: : Avg preop IOP was 19.3 mm Hg. 17/24 patients were currently on prostaglandin, 5 on combination drop, 9 had undergone slt. 2 patients were on 2 IOP lowering meds, another 2 were on 3 medications. Avg IOP on POD1 was 22.5. 16.5% of patients had an iop spike of >10mm Hg (avg 17 mm Hg) and 37.5% had a spike of >5 mm Hg. 7 patients were treated with drops, 5 only discontinued durezol, 4 had no change to regimen. All IOPs were normal at week 6 with average IOP 13 mm Hg.

Conclusions: : Glaucoma patients even without a history of steroid response are more likely to develop IOP spikes after surgery and with any steroid use. Difluprednate is a strong steroid and may cause early and significant elevations of IOP after uneventful cataract surgery. Caution should be used with postoperative difluprednate in patients with a known history of glaucoma.

Keywords: intraocular pressure • drug toxicity/drug effects • cataract 

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