Abstract
Purpose: :
To report on the incidence of endophthalmitis after cataract extraction when using intracameral vancomycin, and to report any suspected complications associated with its use.
Methods: :
This is a retrospective chart review of all patients undergoing cataract surgery by one experienced staff surgeon at Loma Linda University between 2007 and 2011. All patients had received a fixed concentration of vancomycin (2mg/ml) given as a bolus injection into the anterior chamber at the end of the case. Pre-operative, operative, and post-operative data (one day, one week, and one month) was reviewed.
Results: :
After review of 2437 cataract extractions, no cases of endophthalmitis were found. No complications attributable to intracameral vancomycin use were encountered.
Conclusions: :
The review of patients gives further evidence to support the safety and efficacy of intracameral vancomycin in patients undergoing cataract surgery. Multi-center randomized controlled trials evaluating the use of post-operative bolus injection of intracameral vancomycin in cataract surgery are warranted.
Keywords: antibiotics/antifungals/antiparasitics • endophthalmitis • drug toxicity/drug effects