March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Gelatinous And Hard Silicone Spheres In The Rabbit Eviscerated Anophthalmic Cavities
Author Affiliations & Notes
    Ophthalmology, Faculdade de Medicina de Botucatu - UNESP, Botucatu, Brazil
  • Silvana A. Schellini
    Ophthalmology, Faculdade de Medicina de Botucatu - UNESP, Botucatu, Brazil
  • Footnotes
    Commercial Relationships  MAYUMI S. Kanamura, None; Silvana A. Schellini, None
  • Footnotes
    Support  Fundação de Amparo a Pesquisa do Estado de São Paulo - Brazil
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6755. doi:
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      MAYUMI S. KANAMURA, Silvana A. Schellini; Gelatinous And Hard Silicone Spheres In The Rabbit Eviscerated Anophthalmic Cavities. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6755.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the biocompatibility of gelatinous and hard silicone spheres placed in scleral cavities of eviscerated rabbits, comparing them.

Methods: : Prospective and experimental study using 30 rabbits, specie Orictolagus cuniculus, underwent evisceration surgery of the right eye and replacement of orbital volume with spheres composed by gelatinous(soft) or rigid silicone. The animals were sacrificed seven, 30 and 90 days after surgery. The studies parameters were: daily clinical assessment, ultrasound of the orbit 15 days after the procedure, histological analysis of the orbital contents seven, 30 and 90 days after surgery and morphometric evaluation in the pseudocapsule in all the animals. Statistical analysis for comparison between and within groups was done.

Results: : During follow-up occurred three spheres extrusions, two of which belonging to the group of rigid spheres and from gelatinous sphere group. Ultrasound examination showed no inflammation or collections around spheres and good integration with the orbital tissues. The histological evaluation proved both materials had similar response and morphometric evaluation showed thinner pseudocapsule formation around the gelatinous sphere, mainly in the posterior scleral region.

Conclusions: : All the parameters evaluated showed both spheres had good tecidual integration to the orbital tissue in rabbits eviscerated eyes. Therefore, gelatinous silicone sphere induced thinner pseudocapsule formation. The authors agree the gelatinous silicone spheres might be helpful to be used in the anophthalmic cavity reconstruction and suggest new research have to be done to prove it.

Keywords: pathology: experimental • orbit • wound healing 

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