March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Lack Of Influence Of Corneal Thickness On Biomechanical Waveforms And How That Impact In Distinguishing Candidates For Lasik Or Prk
Author Affiliations & Notes
  • Marcony R. Santhiago
    Ophthalmology, Cleveland Clinic Foundation, Cleveland, Ohio
    Ophthalmology, University of Sao Paulo and Rio Laser, Sao Paulo and Rio de Janeiro, Brazil
  • Renato Ambrosio, Jr.
    Ophthalmology, Instituto de Olhos Renato Ambrosio, Rio de Janeiro, Brazil
  • William J. Dupps, Jr.
    Cole Eye Inst and Lerner Rsch Inst,
    Cleveland Clinic, Cleveland, Ohio
  • David Smadja
    Refractive Surgery, Cole Eye Inst, Cleveland Clinic, Paris, France
  • Edgar M. Espana
    Ophthalmology, Cole Eye Institute, Cleveland, Ohio
  • Steven E. Wilson
    Cole Eye Institute,
    Cleveland Clinic, Cleveland, Ohio
  • Footnotes
    Commercial Relationships  Marcony R. Santhiago, None; Renato Ambrosio, Jr., None; William J. Dupps, Jr., None; David Smadja, None; Edgar M. Espana, None; Steven E. Wilson, None
  • Footnotes
    Support  EY10056
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6788. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Marcony R. Santhiago, Renato Ambrosio, Jr., William J. Dupps, Jr., David Smadja, Edgar M. Espana, Steven E. Wilson; Lack Of Influence Of Corneal Thickness On Biomechanical Waveforms And How That Impact In Distinguishing Candidates For Lasik Or Prk. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6788.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

To investigate the performance of thirty-seven Biomechanical Waveforms (WF), Corneal Hysteresis (CH), Corneal Resistance Factor (CRF) in distinguishing patients who are candidate for LASIK or PRK and their correlation with central corneal thickness (CCT).


In this retrospective randomized clinical study, four-hundred eyes of 400 refractive surgery patients who presented for a refractive surgery screening were enrolled. Eyes that had previous refractive or intraocular surgery, or any ocular diseases, such as corneal opacity or irregularity, dry eye, amblyopia, anisometropia, glaucoma, or retinal abnormalities, were excluded. The main outcomes monitored were age, pre-operative spherical equivalent on manifest refraction (MRSE), ultrasonic pachymetry (USP), topographic parameters (keratometry values) and biomechanical parameters (WFs, CH and CRF).


Among the Thirty-seven biomechanical waveforms, seven were statistically significant lower in the PRK-candidate group compared to LASIK group. There was a trend in CH to be lower in the PRK-candidate group. There was a weak correlation between CCT and all the seven waveform parameters (fig.1 and fig. 2) Aspect 1 (r = -0.064), Up Slope 1 (r = -0.027), Height 1 (r = -0.035), Dive 1 (r = -0.088), slew 1 (r = -0.043), and Aspect 1-50% (r = -0.063) and Height 1-50% (r = -0.035). CH and CRF showed decreasing trends as the CCT decreases with high-moderate correlation.


Parameters Aspect 1, Up Slope 1, Height 1, Dive 1, slew 1, and Aspect 1(50) and Height 1(50) showed ability to distinguish LASIK and PRK-candidate groups and no significant correlation with CCT. Supported by Research to Prevent Blindness, New York, NY  


Keywords: refractive surgery: other technologies • refractive surgery: LASIK • refractive surgery: PRK 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.