March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Changes in Choroidal and Optic Nerve Head Blood Flow Regulation During an Experimental Increase in Ocular Perfusion Pressure
Author Affiliations & Notes
  • Doreen Schmidl
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Agnes Boltz
    Department of Clinical Pharmacology,
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Semira Kaya
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Rene M. Werkmeister
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Nikolaus Dragostinoff
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Michael Lasta
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Elzbieta Polska
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Gerhard Garhofer
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • Leopold Schmetterer
    Department of Clinical Pharmacology,
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Doreen Schmidl, None; Agnes Boltz, None; Semira Kaya, None; Rene M. Werkmeister, None; Nikolaus Dragostinoff, None; Michael Lasta, None; Elzbieta Polska, None; Gerhard Garhofer, None; Leopold Schmetterer, None
  • Footnotes
    Support  Austrian Science Funds Project No. P15970 and P21406
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6832. doi:https://doi.org/
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      Doreen Schmidl, Agnes Boltz, Semira Kaya, Rene M. Werkmeister, Nikolaus Dragostinoff, Michael Lasta, Elzbieta Polska, Gerhard Garhofer, Leopold Schmetterer; Changes in Choroidal and Optic Nerve Head Blood Flow Regulation During an Experimental Increase in Ocular Perfusion Pressure. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6832. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The aim of the present study was to compare choroidal blood flow (ChBF) and optic nerve head blood (ONHBF) in response to an increase in ocular perfusion pressure (OPP) induced by isometric exercise.

Methods: : 48 healthy subjects were included. Subjects performed 6 minutes of squatting to increase OPP. Either ONHBF (n = 24) or ChBF (n = 24) was measured continuously by the means of laser Doppler flowmetry. OPP was calculated as 2/3*mean arterial pressure-intraocular pressure.

Results: : The response in blood flow was less pronounced than the response in OPP indicating for some degree of blood flow regulation. ChBF and ONHBF increased during isometric exercise (p < 0.001 each). However, ChBF was better autoregulated in response to isometric exercise than ONHBF (p = 0.023). ChBF remained constant until an OPP of about 60% above baseline, whereas ONHBF started to increase when OPP rose about 40% over baseline. In 3 subjects, an interesting phenomenon was observed: During squatting ONHBF decreased considerably below baseline when OPP fluctuated due to exhaustion, although OPP was still much higher than at baseline.

Conclusions: : The results of the present study indicate that ChBF shows better regulatory properties than ONHBF during isometric exercise, most likely due to the rich neural innervation. In the ONHBF experiments, a slight decrease in OPP during the squatting periods was accompanied by a pronounced decrease in ONH blood flow. Whether this plays a role in ocular disease remains unclear.

Clinical Trial: : http://www.clinicaltrials.gov NCT00912665

Keywords: choroid • optic disc • intraocular pressure 
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